EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Rua das Taipas nº135, 4050‑600, Porto, Portugal.
Laboratório para a Investigação Integrativa e Translacional em Saúde Populacional (ITR), Universidade do Porto, Rua das Taipas nº135, 4050-600, Porto, Portugal.
J Assist Reprod Genet. 2022 Sep;39(9):2077-2087. doi: 10.1007/s10815-022-02569-y. Epub 2022 Aug 20.
Research using gametes and embryos donated by reproductive and third-party donors contributed to substantial, albeit contentious achievements. The views of gamete donors and recipients on donation for research and the underpinning role of attitudes towards research have been seldom explored and are yet to be incorporated into ethical, legal, and regulatory landscapes. From a cultural standpoint, this study adapts and explores psychometric properties of the Portuguese version of the Research Attitudes Questionnaire (RAQ), and analyzes the willingness of gamete donors and recipients to donate gametes and embryos for research and its association with sociodemographic, reproductive characteristics, and attitudes towards research.
Between July 2017 and June 2018, 71 donors and 165 recipients completed a self-administered questionnaire at the Portuguese Public Bank of Gametes. Willingness to donate and attitudes towards research were measured with a 5-point Likert scale. RAQ psychometric characteristics were explored.
Two RAQ components were identified: "trustworthiness of research" and "critical perspective". Most participants were willing to donate gametes and embryos: donors more willing to donate gametes and male recipients more willing to donate gametes and embryos. Higher RAQ scores, indicating a more positive attitude towards research, were observed on the component "trustworthiness of research" among those willing to donate gametes and embryos and on the component "critical perspective" among those willing to donate embryos.
These findings help foster inclusivity, diversity, and responsiveness of research and call for upstream engagement of male and female gamete donors and recipients, promoting a trustworthy, anticipatory, democratic, and people-centered approach to policies, regulations, and practices in human gamete and embryo research.
使用生殖和第三方供体捐赠的配子和胚胎进行的研究取得了重大但有争议的成果。配子供体和受者对研究捐赠的看法，以及对研究的态度的基础作用，很少被探讨，也尚未纳入伦理、法律和监管领域。从文化角度出发，本研究对葡萄牙版研究态度问卷（RAQ）进行了改编和心理测量特性的探索，并分析了配子供体和受者捐赠配子和胚胎进行研究的意愿及其与社会人口统计学、生殖特征和对研究的态度的关系。
2017 年 7 月至 2018 年 6 月，71 名供体和 165 名受者在葡萄牙公共配子银行完成了一份自我管理的问卷。捐赠意愿和对研究的态度采用 5 点李克特量表进行衡量。对 RAQ 的心理测量特性进行了探讨。
确定了 RAQ 的两个组成部分：“研究的可信度”和“批判性观点”。大多数参与者愿意捐赠配子和胚胎：供体更愿意捐赠配子，男性受者更愿意捐赠配子和胚胎。愿意捐赠配子和胚胎的人对“研究的可信度”组成部分的 RAQ 得分较高，表明对研究的态度更为积极，而愿意捐赠胚胎的人对“批判性观点”组成部分的 RAQ 得分较高。
这些发现有助于促进研究的包容性、多样性和对不同人群的响应性，并呼吁对男性和女性配子供体和受者进行上游参与，推动对人类配子和胚胎研究的政策、法规和实践采取值得信赖、前瞻性、民主和以人为本的方法。
