Shalaby Tarek, Grotzer Michael A
Department of Oncology, University Children's Hospital, CH-8032 Zurich, Switzerland.
Int J Mol Sci. 2015 Dec 7;16(12):29103-19. doi: 10.3390/ijms161226150.
Cerebrospinal fluid (CSF) is a readily reachable body fluid that is reflective of the underlying pathological state of the central nervous system (CNS). Hence it has been targeted for biomarker discovery for a variety of neurological disorders. CSF is also the major route for seeding metastases of CNS malignancies and its analysis could be informative for diagnosis and risk stratification of brain cancers. Recently, modern high-throughput, microRNAs (miRNAs) measuring technology has enabled sensitive detection of distinct miRNAs that are bio-chemicallystable in the CSF and can distinguish between different types of CNS cancers. Owing to the fact that a CSF specimen can be obtained with relative ease, analysis of CSF miRNAs could be a promising contribution to clinical practice. In this review, we examine the current scientific knowledge on tumor associated CSF miRNAs that could guide diagnosis of different brain cancer types, or could be helpful in predicting disease progression and therapy response. Finally, we highlight their potential applications clinically as biomarkers and discuss limitations.
脑脊液（CSF）是一种易于获取的体液，它反映了中枢神经系统（CNS）的潜在病理状态。因此，它一直是多种神经系统疾病生物标志物发现的目标。脑脊液也是中枢神经系统恶性肿瘤播散转移的主要途径，其分析对于脑癌的诊断和风险分层可能具有重要意义。最近，现代高通量微小RNA（miRNA）检测技术能够灵敏地检测出在脑脊液中具有生化稳定性且能区分不同类型中枢神经系统癌症的独特miRNA。由于脑脊液标本相对容易获取，脑脊液miRNA分析可能会对临床实践做出有前景的贡献。在这篇综述中，我们研究了目前关于与肿瘤相关的脑脊液miRNA的科学知识，这些知识可以指导不同类型脑癌的诊断，或者有助于预测疾病进展和治疗反应。最后，我们强调了它们作为生物标志物在临床上的潜在应用，并讨论了局限性。
