毛茛叶毛茛中的新对映-贝壳杉烷型二萜糖苷和二苯甲酮

New Ent-Kaurane-Type Diterpene Glycosides and Benzophenone from Ranunculus muricatus Linn.

作者信息

Wu Bi-Ling, Zou Hui-Liang, Qin Fang-Min, Li Hong-Yu, Zhou Guang-Xiong

机构信息

Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University, Guangzhou 510632, China.

出版信息

Molecules. 2015 Dec 15;20(12):22445-53. doi: 10.3390/molecules201219801.

DOI:10.3390/molecules201219801

PMID:26694331

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6332058/

Abstract

Two new ent-kaurane diterpene glycosides, ranunculosides A (1) and B (2), and a new benzophenone, ranunculone C (3), were isolated from the aerial part of Ranunculus muricatus Linn. The chemical structures of compounds 1-3 were established to be (2S)-ent-kauran-2β-ol-15-en-14-O-β-d-glucopyranoside, (2S,4S)-ent-kauran-2β,18-diol-15-en-14-O-β-d-glucopyranoside, and (R)-3-[2-(3,4-dihydroxybenzoyl)-4,5-dihydroxy-phenyl]-2-hydroxylpropanoic acid, respectively, by spectroscopic data and chemical methods. The absolute configuration of 1 was determined by the combinational application of RP-HPLC analysis and Mosher's method.

摘要

从毛茛（Ranunculus muricatus Linn.）的地上部分分离出两种新的对映-贝壳杉烷二萜糖苷，毛茛苷A（1）和B（2），以及一种新的二苯甲酮，毛茛酮C（3）。通过光谱数据和化学方法确定化合物1-3的化学结构分别为(2S)-对映-贝壳杉-2β-醇-15-烯-14-O-β-D-吡喃葡萄糖苷、(2S,4S)-对映-贝壳杉-2β,18-二醇-15-烯-14-O-β-D-吡喃葡萄糖苷和(R)-3-[2-(3,4-二羟基苯甲酰基)-4,5-二羟基苯基]-2-羟基丙酸。通过RP-HPLC分析和莫舍尔方法的联合应用确定了1的绝对构型。