González-Muniesa Pedro, Garcia-Gerique Laura, Quintero Pablo, Arriaza Suyen, Lopez-Pascual Amaya, Martinez J Alfredo
Centre for Nutrition Research, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain ; Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain ; Navarra's Health Research Institute (IDISNA), 31008 Pamplona, Spain.
Centre for Nutrition Research, Department of Nutrition, Food Sciences and Physiology, University of Navarra, Irunlarrea 1, 31008 Pamplona, Spain.
Oxid Med Cell Longev. 2015;2015:8957827. doi: 10.1155/2016/8957827. Epub 2015 Dec 1.
Several studies have shown a pathological oxygenation (hypoxia/hyperoxia) on the adipose tissue in obese subjects. Additionally, the excess of body weight is often accompanied by a state of chronic low-degree inflammation. The inflammation phenomenon is a complex biological response mounted by tissues to combat injurious stimuli in order to maintain cell homeostasis. Furthermore, it is believed that the abnormal oxygen partial pressure occurring in adipose tissue is involved in triggering inflammatory processes. In this context, oxygen is used in modern medicine as a treatment for several diseases with inflammatory components. Thus, hyperbaric oxygenation has demonstrated beneficial effects, apart from improving local tissue oxygenation, on promoting angiogenesis, wound healing, providing neuroprotection, facilitating glucose uptake, appetite, and others. Nevertheless, an excessive hyperoxia exposure can lead to deleterious effects such as oxidative stress, pulmonary edema, and maybe inflammation. Interestingly, some of these favorable outcomes occur under high and low oxygen concentrations. Hereby, we review a potential therapeutic approach to the management of obesity as well as the oxygen-related inflammation accompanying expanded adipose tissue, based on elevated oxygen concentrations. To conclude, we highlight at the end of this review some areas that need further clarification.
多项研究表明，肥胖受试者的脂肪组织存在病理性氧合（缺氧/高氧）情况。此外，体重超标常伴有慢性低度炎症状态。炎症现象是组织为对抗有害刺激以维持细胞内稳态而产生的复杂生物反应。此外，人们认为脂肪组织中出现的异常氧分压参与引发炎症过程。在此背景下，现代医学将氧气用于治疗多种具有炎症成分的疾病。因此，高压氧合除了改善局部组织氧合外，还在促进血管生成、伤口愈合、提供神经保护、促进葡萄糖摄取、增进食欲等方面显示出有益效果。然而，过度暴露于高氧环境会导致诸如氧化应激、肺水肿等有害影响，甚至可能引发炎症。有趣的是，其中一些有利结果在高氧和低氧浓度下均会出现。在此，我们基于升高的氧浓度，综述一种针对肥胖管理以及伴随脂肪组织扩张的氧相关炎症的潜在治疗方法。最后，我们在本综述末尾强调了一些需要进一步阐明的领域。
