Moon Chan Hee, Han Jungwoo, Ohn Young-Hoon, Park Tae Kwann
Department of Ophthalmology, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul 06591, Republic of Korea.
Department of Ophthalmology, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon 14584, Republic of Korea.
J Ophthalmol. 2015;2015:397495. doi: 10.1155/2015/397495. Epub 2015 Nov 30.
Purpose. To investigate the local relationship between quantified global-flash multifocal electroretinogram (mfERG) optic nerve head component (ONHC) and visual field defects in patients with glaucoma. Methods. Thirty-nine patients with glaucoma and 30 normal controls were enrolled. The ONHC amplitude was measured from the baseline to the peak of the second positive deflection of the induced component. The ONHC amplitude was normalized by dividing ONHC amplitude by the average of seven largest ONHC amplitudes. The ONHC amplitude ratio map and ONHC deficiency map were constructed. The local relationship between the ONHC measurements and visual field defects was evaluated by calculating the overlap between the ONHC deficiency maps and visual field defect plots. Results. The mean ONHC amplitude measurements of patients with glaucoma (6.01 ± 1.91 nV/deg(2)) were significantly lower than those of the normal controls (10.29 ± 0.94 nV/deg(2)) (P < 0.001). The average overlap between the ONHC deficiency map and visual field defect plot was 71.4%. The highest overlap (75.0%) was between the ONHC ratios less than 0.5 and the total deviations less than 5%. Conclusions. The ONHC amplitude was reduced in patients with glaucoma compared to that in normal controls. Loss of the ONHC amplitude from the global-flash mfERG showed a high local agreement with visual field defects in patients with glaucoma.
目的。研究青光眼患者定量全视野闪光多焦视网膜电图（mfERG）视神经乳头成分（ONHC）与视野缺损之间的局部关系。方法。纳入39例青光眼患者和30例正常对照者。从诱发成分第二个正波偏转的基线到峰值测量ONHC振幅。通过将ONHC振幅除以七个最大ONHC振幅的平均值对ONHC振幅进行标准化。构建ONHC振幅比图和ONHC缺损图。通过计算ONHC缺损图与视野缺损图之间的重叠来评估ONHC测量值与视野缺损之间的局部关系。结果。青光眼患者的平均ONHC振幅测量值（6.01±1.91 nV/deg²）显著低于正常对照者（10.29±0.94 nV/deg²）（P<0.001）。ONHC缺损图与视野缺损图之间的平均重叠率为71.4%。ONHC比率小于0.5与总偏差小于5%之间的重叠率最高（75.0%）。结论。与正常对照者相比，青光眼患者的ONHC振幅降低。全视野闪光mfERG中ONHC振幅的丧失与青光眼患者的视野缺损在局部具有高度一致性。
