Kaneko Muneyoshi, Machida Shigeki, Hoshi Yuya, Kurosaka Daijiro
Department of Ophthalmology, Iwate Medical University School of Medicine , Uchimaru, Morioka, Iwate , Japan.
Curr Eye Res. 2015 Jan;40(1):77-86. doi: 10.3109/02713683.2014.915575. Epub 2014 May 15.
To determine the effect of glaucoma on the multifocal electroretinograms (ERGs) (mfERGs) elicited by low-frequency stimuli.
Forty-four patients with open-angle glaucoma and 15 normal subjects were studied. The stimulus frequency was 6.25 Hz, and the stimulus was a circle with a 6.8° radius that was centered on the fovea (center). MfERGs were also elicited by a quarter of an annulus placed around the macula (superior/temporal; inferior/temporal; superior/nasal; and inferior/nasal quadrants). The radius of the inner border of the annulus was 6.8° and that of the outer border was 20°. The actual sensitivity was determined by standard automated perimetry. The thickness of the ganglion cell complex (GCC) was measured by optical coherence tomography.
The mfERGs consisted of a negative wave (N1) followed by a positive wave (P1), and followed by a slow negative wave (N2). There were no significant differences in the response densities of N1 and P1 between the normal control and glaucomatous eyes in any areas. The N2 response density was significantly reduced with the severity of glaucoma in the center. There was a significant reduction even at an early stage of glaucoma compared to control values. In the center, the N2 response density was significantly correlated with the GCC thickness and mean sensitivity. However, in other stimulus areas, there was no significant reduction of any components of the mfERGs.
These results suggest that the N2 component of the slow-sequence mfERGs is affected by glaucoma in the central retinal area. Regional variations in the contribution of the retinal ganglion cell activity to the N2 should be considered when examining the mfERGs in glaucoma patients.
确定青光眼对低频刺激诱发的多焦视网膜电图（mfERGs）的影响。
对44例开角型青光眼患者和15名正常受试者进行研究。刺激频率为6.25Hz，刺激物为以中央凹（中心）为中心、半径为6.8°的圆形。多焦视网膜电图也由围绕黄斑放置的四分之一环形区域（上/颞侧；下/颞侧；上/鼻侧；和下/鼻侧象限）诱发。环形区域内边界的半径为6.8°，外边界的半径为20°。实际敏感度通过标准自动视野检查确定。神经节细胞复合体（GCC）的厚度通过光学相干断层扫描测量。
多焦视网膜电图由一个负波（N1）、随后一个正波（P1）、接着一个慢负波（N2）组成。在任何区域，正常对照组和青光眼组眼睛的N1和P1反应密度均无显著差异。在中心区域，N2反应密度随着青光眼严重程度的增加而显著降低。与对照值相比，即使在青光眼早期也有显著降低。在中心区域，N2反应密度与GCC厚度和平均敏感度显著相关。然而，在其他刺激区域，多焦视网膜电图的任何成分均无显著降低。
这些结果表明，慢序列多焦视网膜电图的N2成分受视网膜中央区域青光眼的影响。在检查青光眼患者的多焦视网膜电图时，应考虑视网膜神经节细胞活动对N2贡献的区域差异。
