Dhillon Harnoor, Kaushik Mamta, Sharma Roshni
Department of Conservative Dentistry and Endodontics, Army College of Dental Sciences, Secunderabad, India.
J Biomed Mater Res B Appl Biomater. 2016 May;104(4):676-85. doi: 10.1002/jbm.b.33587. Epub 2015 Dec 24.
Trauma to the dental pulp, physical or microbiologic, can lead to inflammation of the pulp followed by necrosis. The current treatment modality for such cases is non-surgical root canal treatment. The damaged tissue is extirpated and the root canal system prepared. It is then obturated with an inert material such a gutta percha. In spite of advances in techniques and materials, 10%-15% of the cases may end in failure of treatment. Regenerative endodontics combines principles of endodontics, cell biology, and tissue engineering to provide an ideal treatment for inflamed and necrotic pulp. It utilizes mesenchymal stem cells, growth factors, and organ tissue culture to provide treatment. Potential treatment modalities include induction of blood clot for pulp revascularization, scaffold aided regeneration, and pulp implantation. Although in its infancy, successful treatment of damaged pulp tissue has been performed using principles of regenerative endodontics. This field is dynamic and exciting with the ability to shape the future of endodontics. This article highlights the fundamental concepts, protocol for treatment, and possible avenues for research in regenerative endodontics.
牙髓受到物理或微生物创伤可导致牙髓炎症，继而坏死。目前针对此类病例的治疗方式是非手术根管治疗。受损组织被摘除，根管系统被预备。然后用诸如牙胶这样的惰性材料进行充填。尽管技术和材料有所进步，但仍有10% - 15%的病例治疗可能失败。再生牙髓治疗结合了牙髓病学、细胞生物学和组织工程学原理，为炎症性和坏死性牙髓提供了理想的治疗方法。它利用间充质干细胞、生长因子和器官组织培养来进行治疗。潜在的治疗方式包括诱导血凝块实现牙髓血管再生、支架辅助再生和牙髓植入。尽管仍处于起步阶段，但已利用再生牙髓治疗的原理成功治疗了受损的牙髓组织。这个领域充满活力且令人兴奋，有能力塑造牙髓病学的未来。本文重点介绍了再生牙髓治疗的基本概念、治疗方案以及可能的研究途径。
