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用于药物递送的聚乙二醇-聚乳酸嵌段共聚物胶束和聚乳酸-羟基乙酸共聚物-聚乙二醇-聚乳酸-羟基乙酸共聚物溶胶-凝胶

PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels for drug delivery.

作者信息

Cho Hyunah, Gao Jieming, Kwon Glen S

机构信息

Department of Pharmaceutical and Administrative Sciences, St. Louis College of Pharmacy, 4588 Parkview Place, St. Louis, MO 63110, United States.

Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin, 777 Highland Avenue, Madison, WI 53705, United States.

出版信息

J Control Release. 2016 Oct 28;240:191-201. doi: 10.1016/j.jconrel.2015.12.015. Epub 2015 Dec 15.

DOI:10.1016/j.jconrel.2015.12.015
PMID:26699425
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4909590/
Abstract

Poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) micelles and poly(D,L-lactic-co-glycolic acid)-block-polyethylene glycol)-block-poly(D,L-lactic-co-glycolic acid) (PLGA-b-PEG-b-PLGA) sol-gels have been extensively researched for systemic and localized drug delivery applications, respectively, and they have both progressed into humans for paclitaxel, an important yet poorly water-soluble chemotherapeutic agent. In this review article, preclinical and clinical research on PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels that has focused on paclitaxel will be updated, and recent research on other poorly water-soluble anticancer agents and delivery of drug combinations (i.e. multi-drug delivery) that seeks synergistic anticancer efficacy will be summarized. PEG-b-PLA micelles are a first-generation platform for the systemic multi-delivery of poorly water soluble anticancer agents. PLGA-b-PEG-b-PLGA sol-gels are a first-generation platform for the localized multi-drug delivery of water-soluble and/or poorly water-soluble anticancer agents. In summary, PEG-b-PLA micelles and PLGA-b-PEG-b-PLGA sol-gels may safely enable pre-clinical evaluation and clinical translation of poorly water-soluble anticancer agents, especially for promising, rapidly emerging anticancer combinations.

摘要

聚（乙二醇）-嵌段-聚（D，L-乳酸）（PEG-b-PLA）胶束和聚（D，L-乳酸-共-乙醇酸）-嵌段-聚乙二醇）-嵌段-聚（D，L-乳酸-共-乙醇酸）（PLGA-b-PEG-b-PLGA）溶胶-凝胶分别已针对全身和局部药物递送应用进行了广泛研究，并且它们都已进入人体用于紫杉醇，一种重要但水溶性差的化疗药物。在这篇综述文章中，将更新聚焦于紫杉醇的PEG-b-PLA胶束和PLGA-b-PEG-b-PLGA溶胶-凝胶的临床前和临床研究，并总结最近关于其他水溶性差的抗癌药物以及寻求协同抗癌疗效的药物组合递送（即多药递送）的研究。PEG-b-PLA胶束是用于全身多递送水溶性差的抗癌药物的第一代平台。PLGA-b-PEG-b-PLGA溶胶-凝胶是用于水溶性和/或水溶性差的抗癌药物局部多药递送的第一代平台。总之，PEG-b-PLA胶束和PLGA-b-PEG-b-PLGA溶胶-凝胶可以安全地实现水溶性差的抗癌药物的临床前评估和临床转化，特别是对于有前景的、迅速出现的抗癌组合。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/649003ac950f/nihms747282f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/90058c7e5bcb/nihms747282f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/2c8602cd6cc4/nihms747282f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/0c78524a62f1/nihms747282f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/649003ac950f/nihms747282f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/90058c7e5bcb/nihms747282f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/2a5c4a975924/nihms747282f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/dbfd0e9bce55/nihms747282f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/e9a6aa510817/nihms747282f4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7d0/4909590/649003ac950f/nihms747282f7.jpg

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1
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Lancet Oncol. 2015 Jul;16(7):816-29. doi: 10.1016/S1470-2045(15)00051-0. Epub 2015 Jun 16.
2
Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy.用于NQO1靶向肺癌治疗的酯酶可激活的β-拉帕醌前药胶束
J Control Release. 2015 Feb 28;200:201-11. doi: 10.1016/j.jconrel.2014.12.027. Epub 2014 Dec 24.
3
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4
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5
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5
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Adv Drug Deliv Rev. 2015 Aug 30;91:7-22. doi: 10.1016/j.addr.2014.10.001. Epub 2014 Oct 13.
6
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