Ji Y Y, Liu Y F, Wang B Y, Yang D Y
Department of Pathology, Fourth Military Medical College, Shaanxi, People's Republic of China.
Cancer. 1989 Sep 15;64(6):1281-9. doi: 10.1002/1097-0142(19890915)64:6<1281::aid-cncr2820640619>3.0.co;2-7.
The distribution of ferritin in 36 autopsy cases of malignant histiocytosis was investigated by immunocytochemical staining, together with the detection of alpha 1-antichymotrypsin, alpha 1-antitrypsin, lysozyme, S-100 protein, and ricinus communis agglutinin in the consecutive sections. The results showed that ferritin-positive tumor cells were present in every case. The quantity of cellular ferritin in well-differentiated histiocytes was higher than that in atypical histiocytes. Double labeling showed that ferritin and alpha 1-antichymotrypsin might be located either in one tumor cell or in separate cells. Our data suggest that ferritin may be a tumor associated antigen in malignant histiocytosis, playing a regulatory role for tumor cell differentiation.
通过免疫细胞化学染色研究了36例恶性组织细胞增多症尸检病例中铁蛋白的分布情况，并在连续切片中检测了α1-抗糜蛋白酶、α1-抗胰蛋白酶、溶菌酶、S-100蛋白和蓖麻凝集素。结果显示，每例均存在铁蛋白阳性肿瘤细胞。分化良好的组织细胞中细胞铁蛋白的量高于非典型组织细胞。双重标记显示铁蛋白和α1-抗糜蛋白酶可能位于一个肿瘤细胞中或位于不同细胞中。我们的数据表明，铁蛋白可能是恶性组织细胞增多症中的一种肿瘤相关抗原，对肿瘤细胞分化起调节作用。
