Ng H K, Lo S T
Department of Morbid Anatomy, Chinese University of Hong Kong.
Histopathology. 1988 Jul;13(1):79-87. doi: 10.1111/j.1365-2559.1988.tb02005.x.
Antisera to alpha 1-antichymotrypsin, alpha 1-antitrypsin and lysozyme were reacted with 20 cases of glioblastoma multiforme, seven anaplastic astrocytomas, eight astrocytomas, six oligodendrogliomas, four ependymomas and the cerebral cortex from six normal autopsy brains. In addition, two pleomorphic xantho-astrocytomas and two heavily lipidized malignant gliomas were similarly examined. All astrocytic lesions were confirmed with anti-GFAP antisera. Thirty astrocytic tumours (77%), four oligodendrogliomas (67%) and three ependymomas (75%) reacted positively with anti-alpha 1-antichymotrypsin; 25 astrocytic tumours (64%), three oligodendrogliomas (50%) and three ependymomas (75%) showed positive staining for alpha 1-antitrypsin. The pattern of staining with either of these two markers did not correlate with tumour grading. None of the gliomas examined stained positively with anti-lysozyme. Non-neoplastic glial elements did not react with any of the three antisera. The results of this study suggest that staining for alpha 1-antichymotrypsin and alpha 1-antitrypsin is of little value in the differential diagnosis of neuroepithelial or mesenchymal lesions in the brain.
将抗α1 - 抗糜蛋白酶、α1 - 抗胰蛋白酶和溶菌酶的抗血清与20例多形性胶质母细胞瘤、7例间变性星形细胞瘤、8例星形细胞瘤、6例少突胶质细胞瘤、4例室管膜瘤以及6例正常尸检脑的大脑皮质进行反应。此外，对2例多形性黄色星形细胞瘤和2例重度脂质化恶性胶质瘤进行了类似检查。所有星形细胞病变均用抗GFAP抗血清进行确认。30例星形细胞瘤（77%）、4例少突胶质细胞瘤（67%）和3例室管膜瘤（75%）与抗α1 - 抗糜蛋白酶反应呈阳性；25例星形细胞瘤（64%）、3例少突胶质细胞瘤（50%）和3例室管膜瘤（75%）对α1 - 抗胰蛋白酶呈阳性染色。这两种标志物中任何一种的染色模式均与肿瘤分级无关。所检查的胶质瘤均未用抗溶菌酶染色呈阳性。非肿瘤性胶质成分与三种抗血清均无反应。本研究结果表明，α1 - 抗糜蛋白酶和α1 - 抗胰蛋白酶染色在脑内神经上皮或间充质病变的鉴别诊断中价值不大。
