Kesten S, Rebuck A S
Toronto, Western Hospital, Ontario, Canada.
Drugs. 1989 Jul;38(1):160-74. doi: 10.2165/00003495-198938010-00007.
Chronic obstructive pulmonary disease (COPD) is characterised by insidiously progressive airflow limitation. The necessarily multifactorial management programme should include smoking cessation, prevention of infections, bronchodilator and steroid therapy, supplemental oxygen, physical therapy, pulmonary rehabilitation programmes, psychosocial support and treatment of concomitant disease. There have been many advances in medical therapy but some of the notorious controversies remain. New sympathomimetic agents and methylxanthines, as well as the availability of inhaled anticholinergic medications free of toxicity, have led to improvement in symptoms and complications related to COPD. There is a clear place for the judicious use of systemic steroids.
慢性阻塞性肺疾病(COPD)的特征是气流受限呈隐匿性进展。其治疗方案必然是多因素的,应包括戒烟、预防感染、支气管扩张剂和类固醇治疗、补充氧气、物理治疗、肺康复计划、心理社会支持以及合并症的治疗。药物治疗虽已取得诸多进展,但一些著名的争议依然存在。新型拟交感神经药和甲基黄嘌呤,以及无毒性的吸入性抗胆碱能药物的出现,已使与COPD相关的症状和并发症得到改善。合理使用全身性类固醇有明确的作用。