Eaton M L, Green B A, Church T R, McGowan T, Niewoehner D E
Ann Intern Med. 1980 Jun;92(6):758-61. doi: 10.7326/0003-4819-92-6-758.
We studied ventilatory, hemodynamic, and subjective responses to different plasma theophylline concentrations in 10 patients with "irreversible" airflow obstruction. Subjects received theophylline at doses that produced low (9.0 to 12.5 micrograms/mL) and high (17 to 22 micrograms/mL) peak plasma concentrations; subjects also received placebo. A significant (P less than 0.05) dose-related difference in pulmonary function was observed between each treatment. The mean maximal increase in forced expiratory volume at 1 second over placebo was 21.3% for high-dose theophylline and 6.0% for low dose. Both treatments were well tolerated with respect to hemodynamic changes and other adverse effects. Despite improved findings in pulmonary function tests patients were unable to distinguish either treatment from placebo in terms of improvement in breathlessness.
我们研究了10例“不可逆”气流阻塞患者对不同血浆茶碱浓度的通气、血流动力学及主观反应。受试者接受能产生低（9.0至12.5微克/毫升）和高（17至22微克/毫升）血浆峰浓度的茶碱剂量；受试者也接受了安慰剂。在每种治疗之间观察到肺功能有显著（P<0.05）的剂量相关差异。高剂量茶碱组一秒用力呼气量较安慰剂组的平均最大增加量为21.3%，低剂量组为6.0%。两种治疗在血流动力学变化和其他不良反应方面耐受性良好。尽管肺功能测试结果有所改善，但患者在呼吸困难改善方面无法区分任何一种治疗与安慰剂。
