Lu Feng-Mei, Zhou Jian-Song, Zhang Jiang, Xiang Yu-Tao, Zhang Jian, Liu Qi, Wang Xiao-Ping, Yuan Zhen
Bioimaging Core, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.
Mental Health Institute, Second Xiangya Hospital, Central South University, Hunan Province Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Changsha, Hunan 410011, China.
PLoS One. 2015 Dec 29;10(12):e0145668. doi: 10.1371/journal.pone.0145668. eCollection 2015.
Conduct disorder (CD) is characterized by a persistent pattern of antisocial behavior and aggression in childhood and adolescence. Previous task-based and resting-state functional magnetic resonance imaging (fMRI) studies have revealed widespread brain regional abnormalities in adolescents with CD. However, whether the resting-state networks (RSNs) are altered in adolescents with CD remains unknown. In this study, resting-state fMRI data were first acquired from eighteen male adolescents with pure CD and eighteen age- and gender-matched typically developing (TD) individuals. Independent component analysis (ICA) was implemented to extract nine representative RSNs, and the generated RSNs were then compared to show the differences between the CD and TD groups. Interestingly, it was observed from the brain mapping results that compared with the TD group, the CD group manifested decreased functional connectivity in four representative RSNs: the anterior default mode network (left middle frontal gyrus), which is considered to be correlated with impaired social cognition, the somatosensory network (bilateral supplementary motor area and right postcentral gyrus), the lateral visual network (left superior occipital gyrus), and the medial visual network (right fusiform, left lingual gyrus and right calcarine), which are expected to be relevant to the perceptual systems responsible for perceptual dysfunction in male adolescents with CD. Importantly, the novel findings suggested that male adolescents with pure CD were identified to have dysfunctions in both low-level perceptual networks (the somatosensory network and visual network) and a high-order cognitive network (the default mode network). Revealing the changes in the functional connectivity of these RSNs enhances our understanding of the neural mechanisms underlying the modulation of emotion and social cognition and the regulation of perception in adolescents with CD.
品行障碍（CD）的特征是在童年和青少年时期存在持续的反社会行为和攻击行为模式。先前基于任务和静息态功能磁共振成像（fMRI）的研究已经揭示了患有CD的青少年存在广泛的脑区异常。然而，患有CD的青少年的静息态网络（RSN）是否发生改变仍然未知。在本研究中，首先从18名患有单纯CD的男性青少年以及18名年龄和性别匹配的发育正常（TD）个体中获取静息态fMRI数据。实施独立成分分析（ICA）以提取9个代表性的RSN，然后比较生成的RSN以显示CD组和TD组之间的差异。有趣的是，从脑图谱结果中观察到，与TD组相比，CD组在四个代表性RSN中表现出功能连接性降低：前默认模式网络（左额中回），被认为与社会认知受损相关；躯体感觉网络（双侧辅助运动区和右中央后回）；外侧视觉网络（左枕上回）；以及内侧视觉网络（右梭状回、左舌回和右距状裂），预计这些网络与负责患有CD的男性青少年感知功能障碍的感知系统相关。重要的是，这些新发现表明，患有单纯CD的男性青少年在低水平感知网络（躯体感觉网络和视觉网络）和高阶认知网络（默认模式网络）中均存在功能障碍。揭示这些RSN功能连接性的变化有助于我们更好地理解患有CD的青少年情绪和社会认知调节以及感知调节的神经机制。
