Chang Shyue-Luen, Huang Yau-Li, Lee Mei-Ching, Chang Chih-Hsiang, Lin Ying-Fang, Cheng Chun Yu, Hu Sindy
Department of Dermatology, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taoyuan, Taiwan.
Department of Cosmetic Science, Chang Gung University of Science and Technology, Linkou, Taiwan.
Lasers Med Sci. 2016 Feb;31(2):283-7. doi: 10.1007/s10103-015-1852-0. Epub 2015 Dec 29.
There are versatile modalities to achieve noninvasive fat reduction, and most of them have proven to be effective for circumferential reduction of local fat tissue, without any serious or permanent adverse effects. However, the follow-up time is short, ranging from 1 to 24 weeks. Most of the patients would like to know how long will its effect last and whether there is long-term side effect or not. The aim of this study was to assess the long-term efficacy and safety of combination therapy of focused ultrasound and radio frequency for noninvasive body contouring. Thirty-two Asian subjects received three sequential combination therapies of focused ultrasound and radio-frequency treatments every 2 weeks in the abdominal region and were followed up 1 month and 1 year after the last treatment. After a year, 5 patients were loss follow-up and 2 were pregnant. Finally, 25 healthy Asian subjects (18 females and 7 males) were enrolled in this study. Safety parameters and adverse events were recorded. The mean body weight change remained constant without a significant change 1 year after treatment and was 0.1 ± 1.2 kg (p = 0.513). The mean abdominal circumference change between 1 month and 1 year after the last treatment was 0.4 ± 1.2 cm and was not significant (p = 0.169). The relationships between weight change and circumference change of the 23 patients were tested using Spearman's rho correlation coefficient. There was a correlation between weight change and circumference change (0.73; p = 0.000). The procedure was safe without a recordable long-term adverse event. The combination therapies of nonthermally focused ultrasound and radio-frequency treatments for body contouring in the abdominal region are effective and may show positive results for at least a year if patients can maintain their body weight. The procedure is safe without recordable long-term adverse events in this study.
实现非侵入性减脂有多种方式，并且其中大多数已被证明对局部脂肪组织的周径减小有效，且无任何严重或永久性不良反应。然而，随访时间较短，为1至24周。大多数患者想知道其效果能持续多久以及是否存在长期副作用。本研究的目的是评估聚焦超声与射频联合治疗用于非侵入性身体塑形的长期疗效和安全性。32名亚洲受试者在腹部区域每2周接受三次聚焦超声和射频治疗的序贯联合治疗，并在最后一次治疗后1个月和1年进行随访。1年后，5名患者失访，2名患者怀孕。最终，25名健康亚洲受试者（18名女性和7名男性）纳入本研究。记录安全参数和不良事件。治疗1年后平均体重变化保持恒定，无显著变化，为0.1±1.2 kg（p = 0.513）。最后一次治疗后1个月至1年之间的平均腹围变化为0.4±1.2 cm，无显著性差异（p = 0.169）。使用Spearman等级相关系数检验23名患者体重变化与腹围变化之间的关系。体重变化与腹围变化之间存在相关性（0.73；p = 0.000）。该 procedure 是安全的，无可记录的长期不良事件。非热聚焦超声和射频治疗联合用于腹部区域身体塑形是有效的，如果患者能够维持体重，可能至少在一年内显示出积极效果。在本研究中，该 procedure 是安全的，无可记录的长期不良事件。
