Gutierrez Jean L, Bowden Rodney G, Willoughby Darryn S
a Department of Nutrition and Metabolism, University of Texas Medical Branch , Galveston , Texas , USA.
b Department of Health, Human Performance and Recreation, Exercise and Biochemical Nutrition Lab, Baylor University , Waco , Texas , USA.
J Diet Suppl. 2016;13(4):461-71. doi: 10.3109/19390211.2015.1110222. Epub 2015 Dec 30.
Cassia cinnamon has been suggested to lower blood glucose (BG) and serum insulin (SI) due to an improvement in insulin resistance (IR) and sensitivity (IS). This study compared the effects Cassia cinnamon had on calculated IR and IS values and BG and SI in response to an oral glucose tolerance test (OGTT) in young, sedentary, and obese women. On three separate days, 10 women had a fasted venous blood sample obtained. Participants were given 5 g of encapsulated placebo (PLC) or 5 g of encapsulated Cassia cinnamon bark (CASS). Three hours after the initial blood sample, another blood sample was obtained to calculate values for IS and IR. The participants then completed an OGTT by consuming a 75 g glucose solution. Blood was obtained 30, 60, 90, and 120 min following glucose ingestion. IS and IR were not significantly different between placebo and Cassia (p > .05). The peak BG concentration in response to the OGTT was significantly lower at the 30 min time point for CASS, as compared to PLC (140 ± 5.8 and 156 ± 5.2 mg/dL, p = .025); however, there was no significant difference between treatments for SI (p > .05). The area-under-the-curve responses for BG and SI were not significantly different between PLC and CASS (p > .05). This study suggests that a 5 g dose of Cassia cinnamon may reduce the peak BG response and improve glucose tolerance following an OGTT, but with no improvement in IS and IR in young, sedentary, obese women.
由于肉桂能改善胰岛素抵抗（IR）和敏感性（IS），因此有人提出肉桂可降低血糖（BG）和血清胰岛素（SI）。本研究比较了肉桂对年轻、久坐且肥胖女性口服葡萄糖耐量试验（OGTT）后计算得出的IR和IS值以及BG和SI的影响。在三个不同的日子里，10名女性接受了空腹静脉血样本采集。参与者分别服用5克封装的安慰剂（PLC）或5克封装的肉桂树皮（CASS）。在采集初始血样三小时后，再采集一份血样以计算IS和IR值。然后，参与者通过饮用75克葡萄糖溶液完成OGTT。在摄入葡萄糖后的30、60、90和120分钟采集血液。安慰剂组和肉桂组之间的IS和IR无显著差异（p>.05）。与PLC组相比，CASS组在OGTT后30分钟时间点的BG峰值浓度显著更低（分别为140±5.8和156±5.2毫克/分升，p = .025）；然而，两组之间的SI无显著差异（p>.05）。PLC组和CASS组之间BG和SI的曲线下面积反应无显著差异（p>.05）。本研究表明，5克剂量的肉桂可能会降低OGTT后的BG峰值反应并改善葡萄糖耐量，但对年轻、久坐、肥胖女性的IS和IR无改善作用。
