Rodríguez de la Pinta María Luisa, Castro Lareo María Isabel, Ramon Torrell Josep Maria, García de Lomas Juan, Devadiga Raghavendra, Reyes Janet, McCoig Cynthia, Tafalla Monica, García-Corbeira Pilar
Hospital Universitario Puerta de Hierro, C/Joaquín Rodrigo 2, Majadahonda, 28222 Madrid, Spain.
Complejo Hospitalario Universitario, Xubias de Arriba 84, 15006 A Coruña, Spain.
Vaccine. 2016 Feb 17;34(8):1109-14. doi: 10.1016/j.vaccine.2015.12.036. Epub 2015 Dec 22.
This multi-center, hospital-based observational study determined the seroprevalence of pertussis antibodies amongst healthcare professionals from three different hospitals in Spain to ascertain the health status of professionals attending to susceptible groups who are at risk of contracting and transmitting pertussis.
Medical professionals from three hospitals in Spain were recruited for this study (NCT01706224). Serum samples from subjects were assessed for anti-pertussis antibodies by ELISA. The percentage of subjects positive for anti-pertussis antibodies were determined by age-strata, gender, vaccination status, professional level (physicians, nurses, ancillary nurses and midwives), hospital department, number of working years, numbers of hours spent with the patient as well as number of children in the household.
Overall, 31.2% of subjects were seropositive; 3.3% of these healthcare professionals had ELISA values indicative of current or recent infection. There were no significant differences in terms of pertussis prevalence with respect to age, gender, hospital department, profession, number of working years and number of hours spent with patients. These levels of seronegativity amongst healthcare workers further strengthen the rationale for vaccination amongst this specific population against pertussis.
这项基于医院的多中心观察性研究确定了西班牙三家不同医院医护人员中百日咳抗体的血清流行率，以确定照顾有感染和传播百日咳风险的易感人群的专业人员的健康状况。
招募了西班牙三家医院的医学专业人员参与本研究（NCT01706224）。通过酶联免疫吸附测定法（ELISA）评估受试者的血清样本中的抗百日咳抗体。根据年龄分层、性别、疫苗接种状况、专业水平（医生、护士、辅助护士和助产士）、医院科室、工作年限、与患者相处的时长以及家庭中孩子的数量，确定抗百日咳抗体呈阳性的受试者百分比。
总体而言，31.2%的受试者血清呈阳性；这些医护人员中有3.3%的酶联免疫吸附测定值表明存在当前或近期感染。在百日咳流行率方面，年龄、性别、医院科室、职业、工作年限和与患者相处的时长并无显著差异。医护人员中这些血清阴性水平进一步强化了针对这一特定人群接种百日咳疫苗的理论依据。
