Gilliham Matthew, Tyerman Stephen D
Plant Transport and Signalling Lab, ARC Centre of Excellence in Plant Energy Biology and School of Agriculture, Food, and Wine, University of Adelaide, Waite Research Precinct, PMB1, Glen Osmond, SA 5064, Australia.
Plant Transport and Signalling Lab, ARC Centre of Excellence in Plant Energy Biology and School of Agriculture, Food, and Wine, University of Adelaide, Waite Research Precinct, PMB1, Glen Osmond, SA 5064, Australia.
Trends Plant Sci. 2016 Apr;21(4):295-301. doi: 10.1016/j.tplants.2015.11.011. Epub 2015 Dec 23.
γ-Aminobutyric acid (GABA) concentration increases rapidly in tissues when plants encounter abiotic or biotic stress, and GABA manipulation affects growth. This, coupled to GABA's well-described role as a neurotransmitter in mammals, led to over a decade of speculation that GABA is a signal in plants. The discovery of GABA-regulated anion channels in plants provides compelling mechanistic proof that GABA is a legitimate plant-signaling molecule. Here we examine research avenues unlocked by this finding and propose that these plant 'GABA receptors' possess novel properties ideally suited to translating changes in metabolic status into physiological responses. Specifically, we suggest they have a role in signaling altered cycling of tricarboxylic acid (TCA) intermediates during stress via eliciting changes in electrical potential differences across membranes.
当植物遭遇非生物或生物胁迫时，组织中的γ-氨基丁酸（GABA）浓度会迅速增加，且对GABA的调控会影响植物生长。这一点，再加上GABA在哺乳动物中作为神经递质的广为人知的作用，引发了长达十多年的猜测，即GABA是植物中的一种信号分子。植物中GABA调节的阴离子通道的发现提供了令人信服的机制证据，证明GABA是一种合理的植物信号分子。在此，我们研究了这一发现所开启的研究途径，并提出这些植物“GABA受体”具有一些新颖特性，非常适合将代谢状态的变化转化为生理反应。具体而言，我们认为它们在胁迫期间通过引发跨膜电位差的变化，在三羧酸（TCA）中间体循环改变的信号传导中发挥作用。
