Dhaliwal K, Kunchur R, Farhadieh R
St George's NHS Trust, Tooting, London, SW17 0QT, UK.
Plastic & Reconstructive Surgery Department, Australian National University, Canberra ACT 0200, Australia.
J Plast Reconstr Aesthet Surg. 2016 Feb;69(2):e19-26. doi: 10.1016/j.bjps.2015.11.003. Epub 2015 Nov 25.
Distraction osteogenesis (DO) is a widely used technique in plastic and orthopaedic surgery. During the process, mechanical force is applied to fractured bone to enhance the regenerative processes and induce new bone formation. Although there is an abundance of literature on the clinical process of DO, there is a distinct lack of focus on the underlying biological principles governing this process. DO follows the basic premises of tissue engineering. The mechanical stress stimulates mesenchymal stem cell differentiation down an osteoblastic lineage on a matrix background. The aim of this review is to give an overview of the current knowledge of the molecular mechanism governing this process.
牵张成骨术（DO）是整形和矫形外科中广泛应用的一项技术。在此过程中，对骨折部位施加机械力以促进再生过程并诱导新骨形成。尽管关于牵张成骨术临床过程的文献众多，但对于该过程背后的生物学基本原理却明显缺乏关注。牵张成骨术遵循组织工程的基本前提。机械应力在基质背景上刺激间充质干细胞向成骨细胞谱系分化。本综述的目的是概述目前关于控制这一过程的分子机制的知识。
