Ferrer I, Garcia Bach M, Aparicio M A, Acebes J J, Twose J, Isamat F
Departamento de Anatomía Patológica, Hospital Príncipes de España.
Acta Neurochir (Wien). 1989;99(3-4):152-6. doi: 10.1007/BF01402325.
Two patients suffering from diabetes insipidus, with additional symptoms of impaired vision and signs of panhypopituitarism and increased intracranial pressure, showed a normal sella tursica in the X-ray examination of the skull but large, dense space-occupying lesions in the hypothalamus on CT scans of the brain. NMR performed in one patient disclosed suprasellar growth of a hypothalamic lesion. Proliferation of lymphoplasmocytes and mature plasma cells was seen by light microscopic and electromicroscopical examination of biopsy samples in both cases; histiocytes and multinucleated giant cells were absent; tuberculosis, syphilis and sarcoidosis were ruled out by appropriate tests. Plasma cells exhibited polyclonal immunoglobulin expression as revealed by immunocytochemistry using the PAP method. Taken together these features are typical of plasma cell granuloma. Transitory remission after radiotherapy was obtained in one patient.
两名患有尿崩症的患者，伴有视力受损、全垂体功能减退和颅内压升高的额外症状，颅骨X线检查显示蝶鞍正常，但脑部CT扫描显示下丘脑有大的、致密的占位性病变。对其中一名患者进行的核磁共振成像显示下丘脑病变有鞍上生长。在这两个病例中，通过对活检样本进行光学显微镜和电子显微镜检查，可见淋巴浆细胞和成熟浆细胞增殖；未见组织细胞和多核巨细胞；通过适当检测排除了结核、梅毒和结节病。使用PAP法进行免疫细胞化学检测显示，浆细胞呈现多克隆免疫球蛋白表达。综合这些特征是浆细胞肉芽肿的典型表现。其中一名患者放疗后获得短暂缓解。
