Campos Vanessa, Despland Camille, Brandejsky Vaclav, Kreis Roland, Schneiter Philippe, Chiolero Arnaud, Boesch Chris, Tappy Luc
Department of Physiology, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Department of Clinical Research, University of Bern and Institute of Diagnostic Interventional and Pediatric Radiology, University Hospital, Bern, Switzerland.
Obesity (Silver Spring). 2015 Dec;23(12):2335-9. doi: 10.1002/oby.21310.
To test the hypothesis that substituting artificially sweetened beverages (ASB) for sugar-sweetened beverages (SSB) decreases intrahepatocellular lipid concentrations (IHCL) in overweight subjects with high SSB consumption.
About 31 healthy subjects with BMI greater than 25 kg/m(2) and a daily consumption of at least 660 ml SSB were randomized to a 12-week intervention in which they replaced SSBs with ASBs. Their IHCL (magnetic resonance spectroscopy), visceral adipose tissue volume (VAT; magnetic resonance imaging), food intake (2-day food records), and fasting blood concentrations of metabolic markers were measured after a 4-week run-in period and after a 12-week period with ASB or control (CTRL).
About 27 subjects completed the study. IHCL was reduced to 74% of the initial values with ASB (N = 14; P < 0.05) but did not change with CTRL. The decrease in IHCL attained with ASB was more important in subjects with IHCL greater than 60 mmol/l than in subjects with low IHCL. ALT decreased significantly with SSB only in subjects with IHCL greater than 60 mmol/l. There was otherwise no significant effect of ASB on body weight, VAT, or metabolic markers.
In subjects with overweight or obesity and a high SSB intake, replacing SSB with ASB decreased intrahepatic fat over a 12-week period.
检验以下假设，即用人工甜味饮料（ASB）替代含糖饮料（SSB）可降低高糖饮料摄入量的超重受试者的肝细胞内脂质浓度（IHCL）。
约31名体重指数（BMI）大于25kg/m²且每日至少摄入660ml含糖饮料的健康受试者被随机分配至一项为期12周的干预措施，在此期间他们用人工甜味饮料替代含糖饮料。在为期4周的导入期后以及使用人工甜味饮料或对照组（CTRL）干预12周后，测量他们的肝细胞内脂质浓度（磁共振波谱法）、内脏脂肪组织体积（VAT；磁共振成像）、食物摄入量（2天饮食记录）以及代谢标志物的空腹血浓度。
约27名受试者完成了研究。使用人工甜味饮料时，肝细胞内脂质浓度降至初始值的74%（N = 14；P < 0.05），而对照组则无变化。肝细胞内脂质浓度高于60mmol/l的受试者使用人工甜味饮料后肝细胞内脂质浓度的降低幅度比肝细胞内脂质浓度低的受试者更大。仅在肝细胞内脂质浓度高于60mmol/l的受试者中，含糖饮料使丙氨酸氨基转移酶（ALT）显著降低。此外，人工甜味饮料对体重、内脏脂肪组织体积或代谢标志物无显著影响。
在超重或肥胖且高糖饮料摄入量高的受试者中，用人工甜味饮料替代含糖饮料在12周内可降低肝内脂肪。
