Conroy Deirdre A, Kurth Megan E, Strong David R, Brower Kirk J, Stein Michael D
a University of Michigan Addiction Research Center , Ann Arbor , Michigan , USA.
b General Medicine Research, Butler Hospital , Providence , Rhode Island , USA.
J Addict Dis. 2016;35(2):135-43. doi: 10.1080/10550887.2015.1132986. Epub 2016 Jan 4.
Marijuana is the most commonly used recreational drug in the United States. Research on the relationship between marijuana and sleep is still in its infancy. The study examined differences in sleep characteristics between a community sample of daily users, non-daily marijuana users, and non-users. A total of 98 subjects (45 M; 53 F) participated. The mean age was 22.3 (standard deviation = 3.0). There were 53 females and 55% of the sample was Caucasian. Recruitment was done online and via print advertisements in the community. Groups were categorized as non-daily users (n = 29), daily users (n = 49), and non-user controls (n = 20). Sleep was characterized by the Pittsburgh Sleep Quality Index, Insomnia Severity Index, Epworth Sleepiness Scale, and the Morningness Eveningness Questionnaire. A standard cut off score of >10 for the Insomnia Severity Index was found in 38.8% of daily users, 10.3% of non-daily users, and 20% of non-users. Pittsburgh Sleep Quality Index scores in daily users (7.0+/-3.8) were higher than non-daily (4.9+/-3.2) and non-user controls (5.0+/-3.7), p = .02. Insomnia Severity Index scores in daily users (7.9+/-6.1) were higher than non-daily (5.1+/-4.3) and non-user controls (4.3+/-4.8), p = .01. Covariate adjusted regression analyses revealed mean Pittsburgh Sleep Quality Index and Insomnia Severity Index scores were significantly lower for non-daily users and controls relative to the daily users. When adjusting for depression and anxiety, these unique associations were not significant. There were no differences in the Epworth Sleepiness Scale or Morningness Eveningness Questionnaire. Daily marijuana users endorsed more sleep disturbance than non-daily users. Future studies should consider mood in the relationship between marijuana use and sleep.
大麻是美国最常用的消遣性毒品。关于大麻与睡眠之间关系的研究仍处于起步阶段。该研究调查了日常使用者、非日常大麻使用者和非使用者的社区样本在睡眠特征上的差异。共有98名受试者(45名男性;53名女性)参与。平均年龄为22.3岁(标准差=3.0)。有53名女性,样本的55%为白种人。招募通过网络和社区印刷广告进行。分组为非日常使用者(n = 29)、日常使用者(n = 49)和非使用者对照组(n = 20)。通过匹兹堡睡眠质量指数、失眠严重程度指数、爱泼华嗜睡量表和晨型-夜型问卷来描述睡眠情况。失眠严重程度指数标准临界值>10在38.8%的日常使用者、10.3%的非日常使用者和20%的非使用者中出现。日常使用者的匹兹堡睡眠质量指数得分(7.0±3.8)高于非日常使用者(4.9±3.2)和非使用者对照组(5.0±3.7),p = 0.02。日常使用者的失眠严重程度指数得分(7.9±6.1)高于非日常使用者(5.1±4.3)和非使用者对照组(4.3±4.8),p = 0.01。协变量调整回归分析显示,相对于日常使用者,非日常使用者和对照组的匹兹堡睡眠质量指数和失眠严重程度指数平均得分显著更低。在调整抑郁和焦虑因素后,这些独特关联并不显著。爱泼华嗜睡量表或晨型-夜型问卷方面没有差异。日常大麻使用者比非日常使用者认可更多的睡眠干扰。未来研究应考虑大麻使用与睡眠关系中的情绪因素。