Institut de Chimie des Substances Naturelles, CNRS UPR 2301, Université Paris-Saclay , 1, av.de la Terrasse, 91198 Gif-sur-Yvette, France.
Centre de Biophysique Moléculaire, CNRS UPR 4301, Université d'Orléans , Rue Charles Sadron, F-45071 Orléans 2, France.
J Am Chem Soc. 2016 Mar 9;138(9):2913-6. doi: 10.1021/jacs.5b12084. Epub 2016 Jan 4.
We report first prototypes of responsive lanthanide(III) complexes that can be monitored independently in three complementary imaging modalities. Through the appropriate choice of lanthanide(III) cations, the same reactive ligand can be used to form complexes providing detection by (i) visible (Tb(3+)) and near-infrared (Yb(3+)) luminescence, (ii) PARACEST- (Tb(3+), Yb(3+)), or (iii) T1-weighted (Gd(3+)) MRI. The use of lanthanide(III) ions of different natures for these imaging modalities induces only a minor change in the structure of complexes that are therefore expected to have a single biodistribution and cytotoxicity.
我们报告了首例响应性镧系（III）配合物的原型，它们可以在三种互补的成像模式下独立监测。通过适当选择镧系（III）阳离子，可以使用相同的反应性配体形成提供通过（i）可见光（Tb（3+））和近红外（Yb（3+））发光，（ii）PARACEST-（Tb（3+），Yb（3+）），或（iii）T1 加权（Gd（3+））MRI 检测的复合物。对于这些成像模式，使用不同性质的镧系（III）离子仅会导致复合物结构发生微小变化，因此预计它们具有单一的生物分布和细胞毒性。
