Johnson Oluwatosin O, Zhao Ming, Gunn Jordan, Santarsiero Bernard D, Yin Zhi-Qi, Ayoola Gloria A, Coker H A B, Che Chun-Tao
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago , Chicago, Illinois 60612, United States.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos , CMUL Campus, Lagos 100254, Nigeria.
J Nat Prod. 2016 Jan 22;79(1):224-9. doi: 10.1021/acs.jnatprod.5b00924. Epub 2016 Jan 4.
Four new prenylated anthranols, harunganols C-F (1-4), along with kenganthranol A (5), harunganin (6), and ferruginin A (7), were identified from the leaves of Harungana madagascariensis. The structures of compounds 2, 5, and 7 were confirmed by single-crystal X-ray diffraction analysis. Compound 1 is a unique symmetrical anthranol dimer connected via a CH2 group. Compound 4 possesses a unique C-10 hemiketal group. All anthranols were evaluated for their α-glucosidase inhibitory activities. They displayed a higher potency compared to acarbose except for 3 and 4. In particular, harunganol C (1) showed an IC50 value of 1.2 μM.
从马达加斯加哈伦加那树（Harungana madagascariensis）的叶子中鉴定出四种新的异戊烯基化邻氨基苯甲酸醇，即哈伦加诺醇C - F（1 - 4），以及肯甘邻氨基苯甲酸醇A（5）、哈伦加宁（6）和铁锈宁A（7）。化合物2、5和7的结构通过单晶X射线衍射分析得以确证。化合物1是一种通过CH₂基团连接的独特对称邻氨基苯甲酸醇二聚体。化合物4具有一个独特的C - 10半缩酮基团。对所有邻氨基苯甲酸醇进行了α - 葡萄糖苷酶抑制活性评估。除3和4外，它们表现出比阿卡波糖更高的活性。特别是，哈伦加诺醇C（1）的IC₅₀值为1.2 μM。
