Department of TCMs Pharmaceuticals and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China.
Department of TCMs Pharmaceuticals and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 210009, People's Republic of China; Laboratory of Translational Medicine, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, People's Republic of China.
Phytochemistry. 2021 Jun;186:112711. doi: 10.1016/j.phytochem.2021.112711. Epub 2021 Mar 9.
Ten undescribed anthranoids, including three anthraquinone acetals as racemic mixtures, (±)-kenganthranol G-I, and seven prenylated anthranols, (±)-kenganthranol J-M and harunganol G-I, together with thirteen known compounds, were isolated from the stem bark of Harungana madagascariensis. The structures of (±)-kenganthranol G and (±)-kenganthranol J were confirmed by X-ray crystallography. (±)-Kenganthranol G was separated into (+)-kenganthranol G and (-)-kenganthranol G by chiral HPLC and their absolute configurations were established by electronic circular dichroism. (±)-Kenganthranol L displayed α-glucosidase inhibitory activity with an IC of 4.4 μM.
从马达加斯加宽叶嘉兰的茎皮中分离得到了 10 个未描述的蒽酮类化合物，包括 3 个作为外消旋混合物的蒽醌缩醛（±）-kenganthranol G-I，和 7 个芳基化蒽醇（±）-kenganthranol J-M 和 harunganol G-I，以及 13 个已知化合物。（±）-kenganthranol G 和（±）-kenganthranol J 的结构通过 X 射线晶体学确定。（±）-kenganthranol G 通过手性 HPLC 分离为（+）-kenganthranol G 和（-）-kenganthranol G，并通过电子圆二色谱确定其绝对构型。（±）-kenganthranol L 对α-葡萄糖苷酶表现出抑制活性，IC 为 4.4 μM。
