Gökdoğan Çağıl, Genç Aydan, Gülbahar Özlem, Gökdoğan Ozan, Helvacı Ayşe, Bezgin Selin Üstün, Memiş Leyla
Gazi University Hospital, Audiology Department, Ankara, Turkey.
Hacettepe University Hospital, Audiology Department, Ankara, Turkey.
Braz J Otorhinolaryngol. 2016 Mar-Apr;82(2):144-50. doi: 10.1016/j.bjorl.2015.10.008. Epub 2015 Dec 2.
Hyperbilirubinemia is a common health problem in newborns. Its effects can be different according to the level and duration of the hyperbilirubinemia. The toxic effect of bilirubin on the auditory system can be seen as a sensory neural hearing loss or auditory neuropathy spectrum disorder (ANSD).
The purpose of our study was to determine the effects of toxic bilirubin level on the auditory system by using Auditory Brainstem Response audiometry.
Rats are used as animal models due to their low cost and easy attainability. Auditory Brainstem Response was used for auditory assessment. In this study, three groups were established: experimental, control and placebo groups.
In the experimental group, which consists of rats with hyperbilirubinemia, sensory neural hearing loss was found bilaterally in 4 rats (66.67%) and unilaterally in 2 rats (16.67%) and auditory neuropathy spectrum disorder was found unilaterally in 1 rat (8.33%). Auditory Brainstem Response thresholds were significantly elevated compared to control and placebo groups (p<0.05).
Hyperbilirubinemia of newborn rats may result both in sensory neural hearing loss and auditory neuropathy spectrum disorder.
高胆红素血症是新生儿常见的健康问题。其影响会因高胆红素血症的水平和持续时间而有所不同。胆红素对听觉系统的毒性作用可表现为感音神经性听力损失或听觉神经病谱系障碍（ANSD）。
我们研究的目的是通过听觉脑干反应测听法确定毒性胆红素水平对听觉系统的影响。
由于大鼠成本低且易于获取，因此将其用作动物模型。使用听觉脑干反应进行听觉评估。在本研究中，建立了三组：实验组、对照组和安慰剂组。
在由高胆红素血症大鼠组成的实验组中，4只大鼠（66.67%）双侧出现感音神经性听力损失，2只大鼠（16.67%）单侧出现感音神经性听力损失，1只大鼠（8.33%）单侧出现听觉神经病谱系障碍。与对照组和安慰剂组相比，听觉脑干反应阈值显著升高（p<0.05）。
新生大鼠高胆红素血症可能导致感音神经性听力损失和听觉神经病谱系障碍。
