Mu Tong, Hu Honghong, Ma Yanfen, Feng Xiaofang, Zhang Juan, Gu Yaling
School of Agriculture, Ningxia University, Yinchuan, China.
Front Nutr. 2021 Nov 25;8:765147. doi: 10.3389/fnut.2021.765147. eCollection 2021.
Milk fat is the most important and energy-rich substance in milk and plays an important role in the metabolism of nutrients during human growth and development. It is mainly used in the production of butter and yogurt. Milk fat not only affects the flavor and nutritional value of milk, but also is the main target trait of ruminant breeding. There are many key genes involve in ruminant milk fat synthesis, including ACSS2, FASN, ACACA, CD36, ACSL, SLC27A, FABP3, SCD, GPAM, AGPAT, LPIN, DGAT1, PLIN2, XDH, and BTN1A1. Taking the synthesis of fatty acids (FA) and intaking of long-chain fatty acids (LCFA) in blood to the end of lipid droplet secretion as the mainline, this manuscript elucidates the complex regulation model of key genes in mammary epithelial cells (MECs) in ruminant milk fat synthesis, and constructs the whole regulatory network of milk fat synthesis, to provide valuable theoretical basis and research ideas for the study of milk fat regulation mechanism of ruminants.
乳脂肪是牛奶中最重要且富含能量的物质，在人类生长发育过程中的营养物质代谢中发挥着重要作用。它主要用于生产黄油和酸奶。乳脂肪不仅影响牛奶的风味和营养价值，也是反刍动物育种的主要目标性状。反刍动物乳脂肪合成涉及许多关键基因，包括ACSS2、FASN、ACACA、CD36、ACSL、SLC27A、FABP3、SCD、GPAM、AGPAT、LPIN、DGAT1、PLIN2、XDH和BTN1A1。本文以脂肪酸（FA）的合成以及血液中长链脂肪酸（LCFA）摄取至脂滴分泌结束为主线，阐明反刍动物乳腺上皮细胞（MECs）中关键基因在乳脂肪合成中的复杂调控模式，并构建乳脂肪合成的整体调控网络，为反刍动物乳脂肪调控机制的研究提供有价值的理论依据和研究思路。
