Gizard Florence, Fernandez Anne, De Vadder Filipe
Mammalian Cell Biology Group, Institute of Human Genetics UMR9002, CNRS-University of Montpellier, Montpellier, France.
Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, École Normale Supérieure de Lyon, Centre National de la Recherche Scientifique, Université Claude Bernard Lyon 1, UMR5242, Lyon, France.
Nutr Metab Insights. 2020 Dec 14;13:1178638820980490. doi: 10.1177/1178638820980490. eCollection 2020.
The gut microbiota is now recognized as a major contributor to the host's nutrition, metabolism, immunity, and neurological functions. Imbalanced microbiota (ie, dysbiosis) is linked to undernutrition-induced stunting, inflammatory and metabolic diseases, and cancers. Skeletal muscle also takes part in the interorgan crosstalk regulating substrate metabolism, immunity, and health. Here, we review the reciprocal influence of gut microbiota and skeletal muscle in relation to juvenile growth, performance, aging, and chronic diseases. Several routes involving the vascular system and organs such as the liver and adipose tissue connect the gut microbiota and skeletal muscle, with effects on fitness and health. Therapeutic perspectives arise from the health benefits observed with changes in gut microbiota and muscle activity, further encouraging multimodal therapeutic strategies.
肠道微生物群现在被认为是宿主营养、代谢、免疫和神经功能的主要贡献者。微生物群失衡（即生态失调）与营养不良引起的发育迟缓、炎症和代谢性疾病以及癌症有关。骨骼肌也参与调节底物代谢、免疫和健康的器官间串扰。在这里，我们综述了肠道微生物群与骨骼肌在青少年生长、性能、衰老和慢性疾病方面的相互影响。涉及血管系统以及肝脏和脂肪组织等器官的几条途径将肠道微生物群与骨骼肌连接起来，对健康和体能产生影响。肠道微生物群和肌肉活动变化所带来的健康益处带来了治疗前景，进一步推动了多模式治疗策略的发展。
