Plourde Mélanie, Jew Stephanie, Cunnane Stephen C, Jones Peter Jh
Research Center on Aging and Departments of Medicine, and Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, Québec, Canada.
Nutr Rev. 2008 Jul;66(7):415-21. doi: 10.1111/j.1753-4887.2008.00051.x.
Conjugated linoleic acids (CLA) are positional and geometric isomers of linoleic acid. In animals, CLA consumption reduces body fat but results in humans are less conclusive. This review of the literature on CLA and loss of body fat or body weight in humans was conducted to explore the reasons for the discrepancy between animal and clinical trials. It indicates that the incongruity between human and animal data is largely related to methodological differences in the experimental design, including age and gender and, to a lesser extent, to CLA dose and isomers. The relatively unknown metabolic fate of CLA in humans may also be a contributing factor that helps explain the lack of consistency for CLA efficacy across studies.
共轭亚油酸（CLA）是亚油酸的位置异构体和几何异构体。在动物中，食用CLA可减少体脂，但对人类的影响尚无定论。本文对关于CLA与人体体脂减少或体重减轻的文献进行综述，以探究动物试验和临床试验结果存在差异的原因。结果表明，人与动物数据不一致在很大程度上与实验设计中的方法学差异有关，包括年龄和性别，在较小程度上还与CLA剂量和异构体有关。CLA在人体内相对未知的代谢去向也可能是一个促成因素，有助于解释不同研究中CLA功效缺乏一致性的现象。
