Coad N R, Hain W R
Department of Anaesthetics, University Hospital, Queen's Medical Centre, Nottingham.
Ann R Coll Surg Engl. 1989 Jul;71(4):245-8.
A comparative trial between three different dosage regimens of bupivacaine administered by the caudal route, used for the prevention of postoperative pain in children undergoing elective inguinal herniotomy or ligation of patient processus vaginalis was undertaken. The regimens compared were bupivacaine 0.25% (1 ml/kg), bupivacaine 0.25% or 0.5%: (Age (years +2)/10 ml per dermatome to be blocked. This being calculated for inguinal surgery to be Age (years) + 2 ml. A linear analogue pain scale was used to evaluate pain, all three regimens being found to produce excellent analgesia, there being no significant difference between the pain scores of the three groups. Time to onset of analgesia, as indicated by changes in intraoperative heart rate in response to surgical stimulation were also similar in all groups. No evidence of postoperative motor weakness or disturbance of bladder function was found and there were no symptoms or signs attributable to local anaesthetic toxicity.
进行了一项比较试验,比较通过骶管途径给予布比卡因的三种不同剂量方案,用于预防择期腹股沟疝修补术或鞘状突高位结扎术患儿的术后疼痛。比较的方案为布比卡因0.25%(1毫升/千克)、布比卡因0.25%或0.5%:(年龄(岁)+2)/每要阻滞的皮节10毫升。对于腹股沟手术,计算得出为年龄(岁)+2毫升。使用线性模拟疼痛量表评估疼痛,发现所有三种方案均产生了出色的镇痛效果,三组的疼痛评分之间无显著差异。所有组中,术中因手术刺激导致心率变化所表明的镇痛起效时间也相似。未发现术后运动无力或膀胱功能障碍的证据,也没有可归因于局部麻醉药毒性的症状或体征。