Pattrick M, Heptinstall S, Doherty M
Rheumatology Unit, City Hospital, Nottingham.
Ann Rheum Dis. 1989 Jul;48(7):547-9. doi: 10.1136/ard.48.7.547.
Feverfew, reputed by folklore to be effective in arthritis, has in vitro properties that could be beneficial in the control of inflammatory disease. Forty one female patients with symptomatic rheumatoid arthritis received either dried chopped feverfew (70-86 mg) or placebo capsules once daily for six weeks. Allocation was random and not known by patient or observer. Variables assessed included stiffness, pain (visual analogue scale), grip strength, articular index, full blood count, erythrocyte sedimentation rate, urea, creatinine, C reactive protein, complement breakdown products (C3dg), rheumatoid factor titre, immunoglobulins (IgG, IgA, IgM), functional capacity, and patient and observer global opinions. One patient (placebo) withdrew after three days and was not included in the analysis. Treatment and placebo groups (20 patients each) were well matched at entry. No important differences between the clinical or laboratory variables of the groups were observed during the six week period. This study therefore shows no apparent benefit from oral feverfew in rheumatoid arthritis.
小白菊，民间认为对关节炎有效，其体外特性可能对控制炎症性疾病有益。41名有症状的类风湿性关节炎女性患者，每天服用一次干燥切碎的小白菊（70 - 86毫克）或安慰剂胶囊，持续六周。分配是随机的，患者和观察者均不知情。评估的变量包括僵硬程度、疼痛（视觉模拟评分）、握力、关节指数、全血细胞计数、红细胞沉降率、尿素、肌酐、C反应蛋白、补体裂解产物（C3dg）、类风湿因子滴度、免疫球蛋白（IgG、IgA、IgM）、功能能力以及患者和观察者的总体评价。一名患者（安慰剂组）在三天后退出，未纳入分析。治疗组和安慰剂组（每组20名患者）在入组时匹配良好。六周期间，两组的临床或实验室变量未观察到重要差异。因此，本研究表明口服小白菊对类风湿性关节炎无明显益处。
