Johnson E S, Kadam N P, Hylands D M, Hylands P J
Br Med J (Clin Res Ed). 1985 Aug 31;291(6495):569-73. doi: 10.1136/bmj.291.6495.569.
Seventeen patients who ate fresh leaves of feverfew daily as prophylaxis against migraine participated in a double blind placebo controlled trial of the herb: eight patients received capsules containing freeze dried feverfew powder and nine placebo. Those who received placebo had a significant increase in the frequency and severity of headache, nausea, and vomiting with the emergence of untoward effects during the early months of treatment. The group given capsules of feverfew showed no change in the frequency or severity of symptoms of migraine. This provides evidence that feverfew taken prophylactically prevents attacks of migraine, and confirmatory studies are now indicated, preferably with a formulation controlled for sesquiterpene lactone content, in migraine sufferers who have never treated themselves with this herb.
17名每天食用小白菊鲜叶以预防偏头痛的患者参与了一项针对该草药的双盲安慰剂对照试验：8名患者服用含有冻干小白菊粉末的胶囊，9名患者服用安慰剂。服用安慰剂的患者在治疗的最初几个月出现了不良影响，头痛、恶心和呕吐的频率及严重程度显著增加。服用小白菊胶囊的组偏头痛症状的频率或严重程度没有变化。这证明预防性服用小白菊可预防偏头痛发作，现在需要进行验证性研究，最好是使用对倍半萜内酯含量进行控制的制剂，针对从未使用过这种草药进行自我治疗的偏头痛患者。
