Braunwald N S
Division of Cardiac Surgery, Brigham and Women's Hospital, Boston, Massachusetts 02115.
Ann Thorac Surg. 1989 Sep;48(3 Suppl):S1-3. doi: 10.1016/0003-4975(89)90615-2.
In 1959, a prosthetic mitral valve of flexible polyurethane with Teflon chordae tendineae was designed and fabricated. After a series of experiments in dogs carried out at the Clinic of Surgery at the National Heart Institute, on March 11, 1960, this valve was used as a total replacement of the mitral valve of a 44-year-old woman with mitral regurgitation. After an uneventful postoperative course, she was discharged from the hospital and did well thereafter, but died suddenly, presumably of an arrhythmia, 4 months after operation.
1959年，一种带有聚四氟乙烯腱索的柔性聚氨酯人工二尖瓣被设计并制造出来。在国立心脏研究所外科诊所对狗进行了一系列实验后，1960年3月11日，这个瓣膜被用于一位患有二尖瓣反流的44岁女性二尖瓣的完全置换。术后过程平稳，她出院后情况良好，但在术后4个月突然死亡，推测是死于心律失常。
