一种基于异质金纳米星核-银纳米颗粒卫星组件的表面增强拉曼散射活性传感器，用于超灵敏检测黄曲霉毒素B1。
A SERS-active sensor based on heterogeneous gold nanostar core-silver nanoparticle satellite assemblies for ultrasensitive detection of aflatoxinB1.
作者信息
Li Aike, Tang Lijuan, Song Dan, Song Shanshan, Ma Wei, Xu Liguang, Kuang Hua, Wu Xiaoling, Liu Liqiang, Chen Xin, Xu Chuanlai
机构信息
Cereals & Oils Nutrition Research Group, Academy of Science & Technology of State Administration of Grain, Beijing 100037, People's Republic of China.
State Key Lab of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, JiangSu 214122, People's Republic of China.
出版信息
Nanoscale. 2016 Jan 28;8(4):1873-8. doi: 10.1039/c5nr08372a.
A surface-enhanced Raman scattering (SERS) sensor based on gold nanostar (Au NS) core-silver nanoparticle (Ag NP) satellites was fabricated for the first time to detect aflatoxinB1 (AFB1). We constructed the SERS sensor using AFB1 aptamer (DNA1)-modified Ag satellites and a complementary sequence (DNA2)-modified Au NS core. The Raman label (ATP) was modified on the surface of Ag satellites. The SERS signal was enhanced when the satellite NP was attached to the Au core NS. The AFB1 aptamer on the surface of Ag satellites would bind to the targets when AFB1 was present in the system, Ag satellites were then removed and the SERS signal decreased. This SERS sensor showed superior specificity for AFB1 and the linear detection range was from 1 to 1000 pg mL(-1) with the limit of detection (LOD) of 0.48 pg mL(-1). The excellent recovery experiment using peanut milk demonstrated that the sensor could be applied in food and environmental detection.
首次制备了一种基于金纳米星（Au NS）核-银纳米颗粒（Ag NP）卫星结构的表面增强拉曼散射（SERS）传感器，用于检测黄曲霉毒素B1（AFB1）。我们使用黄曲霉毒素B1适配体（DNA1）修饰的银卫星和互补序列（DNA2）修饰的金纳米星核构建了SERS传感器。拉曼标记物（ATP）修饰在银卫星表面。当卫星纳米颗粒附着到金核纳米星上时，SERS信号增强。当系统中存在AFB1时，银卫星表面的AFB1适配体将与靶标结合，然后银卫星被移除，SERS信号降低。该SERS传感器对AFB1表现出优异的特异性，线性检测范围为1至1000 pg mL(-1)，检测限（LOD）为0.48 pg mL(-1)。使用花生奶进行的出色回收率实验表明，该传感器可应用于食品和环境检测。
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