Abenavoli Ludovico, DI Renzo Laura, Guzzi Pietro Hiram, Pellicano Rinaldo, Milic Natasa, DE Lorenzo Antonino
Department of Health Sciences, University "Magna Græcia", Catanzaro, Italy; Division of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Division of Clinical Nutrition and Nutrigenomics, Department of Biomedicine and Prevention, University of Rome "Tor Vergata", Rome, Italy.
Clujul Med. 2015;88(4):489-93. doi: 10.15386/cjmed-595. Epub 2015 Nov 15.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the general population. Overweight is a common condition in patients with NAFLD, and body composition (BC) assessment is useful to evaluate nutritional status and the efficacy of nutritional strategies. A valid tool for assessing BC is dual-energy X-ray absorptiometry (DXA). Adiponectin has been shown to be relevant to the pathogenesis of NAFLD. The aim of this observational study is to define the relationship between the severity of NAFLD, the central fat mass evaluated by DXA, and the circulating levels of adiponectin.
The study was carried out in 31 overweight patients. The degree of liver steatosis was evaluated by ultrasound (US) examination. Anthropometric parameters were measured according to standard methods. Fasting glucose and insulin level were used also to calculate insulin resistance (IR), according to the homeostasis model assessment-insulin resistance (HOMA-IR). The enzyme-linked immunosorbent assay technique was performed to dose fasting serum levels of adiponectin.
NAFLD progression was significantly associated with increased central fat (p<0.05). Using DXA, we quantified the regional distribution of adipose tissue and found the expected association between central fat and the US severity of NAFLD. Serum levels of adiponectin, were inversely related to NAFLD progression (p<0.05).
BC evaluated by anthropometry and DXA, may be used as indicator of NAFLD severity in overweight patients. The evaluation of BC in clinical practice, can improve the nutritional strategies and follow-up. In the clinical setting adiponectin may represent a potential marker for the staging of NAFLD.
非酒精性脂肪性肝病（NAFLD）是普通人群中最常见的慢性肝病。超重是NAFLD患者的常见情况，身体成分（BC）评估有助于评估营养状况和营养策略的效果。双能X线吸收法（DXA）是评估BC的有效工具。脂联素已被证明与NAFLD的发病机制相关。本观察性研究的目的是确定NAFLD的严重程度、通过DXA评估的中心脂肪量与脂联素循环水平之间的关系。
该研究对31名超重患者进行。通过超声（US）检查评估肝脏脂肪变性程度。按照标准方法测量人体测量参数。还根据稳态模型评估-胰岛素抵抗（HOMA-IR），使用空腹血糖和胰岛素水平计算胰岛素抵抗（IR）。采用酶联免疫吸附测定技术测定空腹血清脂联素水平。
NAFLD进展与中心脂肪增加显著相关（p<0.05）。使用DXA，我们量化了脂肪组织的区域分布，并发现中心脂肪与NAFLD的US严重程度之间存在预期的关联。脂联素血清水平与NAFLD进展呈负相关（p<0.05）。
通过人体测量和DXA评估的BC，可作为超重患者NAFLD严重程度的指标。在临床实践中评估BC，可以改善营养策略和随访。在临床环境中，脂联素可能是NAFLD分期的潜在标志物。
