Robertson M M
Academic Department of Psychiatry, University College, Middlesex Hospital, London.
Br J Psychiatry. 1989 Feb;154:147-69. doi: 10.1192/bjp.154.2.147.
The Gilles de la Tourette Syndrome is a movement disorder characterised by both motor and vocal (phonic) tics. It was once thought to be rare, and the literature until the 1970s consisted predominantly of case reports, both highlighting the fascinating clinical manifestations and speculating as to their aetiology. Many areas of GTS are under investigation, including the neurology, psychopathology, neurophysiology, biochemistry, and genetics. This review briefly considers early descriptions of GTS as well as current research, highlighting the areas of agreement and controversy.
Gilles de la Tourette综合征是一种运动障碍性疾病,其特征为运动性和发声(语音)性抽动。它曾被认为很罕见,直到20世纪70年代的文献主要都是病例报告,既突出了其迷人的临床表现,也对其病因进行了推测。GTS的许多领域都在研究中,包括神经学、精神病理学、神经生理学、生物化学和遗传学。这篇综述简要回顾了GTS的早期描述以及当前的研究,突出了共识和争议的领域。