Cuneo W D, Snider D E
Permanente Medical Group, Kaiser Permanente Medical Care Program, Oakland, California.
Clin Chest Med. 1989 Sep;10(3):375-80.
A major determinant of the outcome of tuberculosis treatment is patient compliance; nevertheless, 20 to 50 per cent of patients fail to complete therapy. The consequences of failure to complete therapy include prolonged communicability, relapse, prolonged and more expensive therapy, development of drug resistance, and death. Noncompliance is a significant factor leading to the persistence of tuberculosis in the United States. Although one-to-one counseling offers the greatest impact for improving compliance, other strategies, such as the use of enablers, incentives, and directly observed therapy, are important as well.
结核病治疗结果的一个主要决定因素是患者的依从性；然而，20%至50%的患者未能完成治疗。未完成治疗的后果包括传染性延长、复发、治疗时间延长且费用更高、产生耐药性以及死亡。不依从是导致美国结核病持续存在的一个重要因素。虽然一对一咨询对提高依从性的影响最大，但其他策略，如使用辅助人员、激励措施和直接观察治疗，也很重要。
