Doumat George, El Zein Joumane, Mehta Geneva D, Zhu Zhaozhong, Espinola Janice A, Sullivan Ashley F, Hasegawa Kohei, Camargo Carlos A
Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas, USA.
Thorax. 2025 Feb 17;80(3):180-183. doi: 10.1136/thorax-2024-222099.
The association between early childhood serum 25-hydroxyvitamin D (25(OH)D) and eosinophilic asthma remains unclear. We investigated this association using multicentre prospective data from 584 children with a history of bronchiolitis requiring hospitalisation (high-risk population). Low serum 25(OH)D levels (<20 ng/mL) were associated with increased odds of developing eosinophilic asthma (adjusted OR 2.33; 95% CI 1.23, 4.40; p=0.01) as compared with children with serum 25(OH)D of 20-39.9 ng/mL. Our data facilitate further investigation into the potential role of early-life vitamin D supplementation among children with a history of severe bronchiolitis and eosinophilia for preventing childhood asthma.
儿童早期血清25-羟基维生素D（25(OH)D）与嗜酸性粒细胞性哮喘之间的关联仍不明确。我们利用来自584名有毛细支气管炎住院史儿童（高危人群）的多中心前瞻性数据对这种关联进行了调查。与血清25(OH)D水平为20 - 39.9 ng/mL的儿童相比，低血清25(OH)D水平（<20 ng/mL）与发生嗜酸性粒细胞性哮喘的几率增加相关（校正比值比2.33；95%置信区间1.23, 4.40；p = 0.01）。我们的数据有助于进一步研究早期补充维生素D在有严重毛细支气管炎和嗜酸性粒细胞增多病史的儿童预防儿童哮喘方面的潜在作用。
