Li Wei, Yang Xueqiong, Yang Yabin, Duang Rongting, Chen Guangyi, Li Xiaozhan, Li Qiling, Qin Shaohuan, Li Shuquan, Zhao Lixing, Ding Zhongtao
a School of Chemical Science and Technology , Yunnan University , Kunming , People's Republic of China.
b School of Pharmaceutical Sciences , Kunming Medical University , Kunming , People's Republic of China.
Nat Prod Res. 2016 Nov;30(22):2616-2619. doi: 10.1080/14786419.2015.1129328. Epub 2016 Jan 8.
Fourteen metabolites with various structure types were isolated from endophytic Chaetomium globosum. Five compounds were separated from genus Chaetomium for the first time. Some compounds exhibited remarkable inhibition against phytopathogenic fungi causing root rot of Panax notoginseng. Compounds 1-5 had significant DPPH-free radical-scavenging activity. Compounds 3 and 5 indicated significant inhibitions against the acetylcholinesterase (AChE). From preliminary structure-activity relationship, it was found that the oxygenic five-membered ring of 3 and 5 was crucial in the anti-AChE activity. These structures provide new templates for the potential treatment and management of plant diseases and Alzheimer disease.
从内生球毛壳菌中分离出14种具有不同结构类型的代谢产物。其中5种化合物是首次从球毛壳属中分离得到。一些化合物对引起三七根腐病的植物病原真菌表现出显著的抑制作用。化合物1 - 5具有显著的清除DPPH自由基活性。化合物3和5对乙酰胆碱酯酶（AChE）有显著抑制作用。从初步的构效关系发现，化合物3和5的含氧五元环在抗AChE活性中起关键作用。这些结构为植物病害和阿尔茨海默病的潜在治疗和管理提供了新的模板。
