Song Fuhang, Lin Rui, Yang Na, Jia Jia, Wei Shangzhu, Han Jiahui, Li Jiangpeng, Bi Hongkai, Xu Xiuli
School of Light Industry, Beijing Technology and Business University, Beijing 100048, China.
School of Ocean Sciences, China University of Geosciences, Beijing 100083, China.
Antibiotics (Basel). 2021 Apr 3;10(4):377. doi: 10.3390/antibiotics10040377.
Four new secondary metabolites, including one [anthracenone-xanthene] derivative aspergiloxathene A (), one penicillide analogue, Δ-1'-dehydropenicillide (), and two new phthalide derivatives, 5-methyl-3-methoxyepicoccone () and 7-carboxy-4-hydroxy-6-methoxy-5-methylphthalide (), together with four known compounds, yicathin C (), dehydropenicillide (), 3-methoxyepicoccone (), 4-hydroxy-6-methoxy-5-methylphthalide (), were identified from the marine-derived fungus sp. IMCASMF180035. Their structures were determined by spectroscopic data, including high-resolution electrospray ionization mass spectrometry (HRESIMS), 1D and 2D nuclear magnetic resonance (NMR) techniques. Compound was identified as the first jointed molecule by xanthene and anthracenone moieties possessing an unprecedented carbon skeleton with spiro-ring system. All compounds were evaluated activities against , methicillin resistant (MRSA), , , , and Compound showed significant inhibitory effects against and MRSA, with minimum inhibitory concentration (MIC) values of 5.60 and 22.40 µM. Compounds and exhibited potent antibacterial activities against , with MIC values of 21.73 and 21.61 µM, respectively.
从海洋来源的真菌 Aspergillus sp. IMCASMF180035 中鉴定出四种新的次生代谢产物，包括一种 [蒽酮 - 呫吨] 衍生物曲霉呫吨菌素 A（）、一种青霉噻唑类似物 Δ-1'-脱氢青霉噻唑（）、两种新的邻苯二甲酸酯衍生物 5-甲基-3-甲氧基表棒曲霉素（）和 7-羧基-4-羟基-6-甲氧基-5-甲基邻苯二甲酸酯（），以及四种已知化合物，异卡亭 C（）、脱氢青霉噻唑（）、3-甲氧基表棒曲霉素（）、4-羟基-6-甲氧基-5-甲基邻苯二甲酸酯（）。通过光谱数据确定了它们的结构，包括高分辨率电喷雾电离质谱（HRESIMS）、一维和二维核磁共振（NMR）技术。化合物 被鉴定为第一个由呫吨和蒽酮部分连接的分子，具有前所未有的带有螺环系统的碳骨架。评估了所有化合物对金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌（MRSA）、大肠杆菌、枯草芽孢杆菌、白色念珠菌和新型隐球菌的活性。化合物 对金黄色葡萄球菌和 MRSA 显示出显著的抑制作用，最低抑菌浓度（MIC）值分别为 5.60 和 22.40 μM。化合物 和 对大肠杆菌表现出强效抗菌活性，MIC 值分别为 21.73 和 21.61 μM。
