Rozenberg Robert, Mankowski Robert T, van Loon Luc J C, Langendonk Janneke G, Sijbrands Eric J G, van den Meiracker Anton H, Stam Henk J, Praet Stephan F E
Subdivision MOVEFIT-Sports Medicine, Department of Rehabilitation Medicine, Erasmus University Medical Center, Wytemaweg 80, 3000 CA, Rotterdam, The Netherlands.
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands.
Eur J Med Res. 2016 Jan 8;21:1. doi: 10.1186/s40001-015-0194-5.
The study investigated the feasibility and potential outcome measures during acute hyperoxia in type 2 diabetes patients (DM2).
Eleven DM2 patients (7 men and 4 women) were included in the study. The patients cycled (30 min at 20% Wmax) whilst breathing three different supplemental oxygen flows (SOF, 5, 10, 15 L min(-1)). During hyperoxic exercise, arterial blood gases and intra-arterial blood pressure measurements were obtained.
Arterial pO2 levels increased significantly (ANOVA, p < 0.05) with SOF: 13.9 ± 1.2 (0 L min(-1)); 18.5 ± 1.5 (5 L min(-1)); 21.7 ± 1.7 (10 L min(-1)); 24.0 ± 2.3 (15 L min(-1)). Heart rate (HR) and pH increased significantly after terminating administration of hyperoxic air.
An SOF of 15 L min(-1) appears to be more effective than 5 or 10 L min(-1). Moreover, HR, blood pressure, blood lactate and pH are not recommended as primary outcome measures.
本研究调查了2型糖尿病患者（DM2）在急性高氧期间的可行性及潜在的结果指标。
11名DM2患者（7名男性和4名女性）纳入本研究。患者在呼吸三种不同补充氧气流量（SOF，5、10、15 L min⁻¹）的同时进行30分钟的骑行运动（强度为最大摄氧量的20%）。在高氧运动期间，测量动脉血气和动脉内血压。
随着SOF增加，动脉血氧分压水平显著升高（方差分析，p < 0.05）：13.9 ± 1.2（0 L min⁻¹）；18.5 ± 1.5（5 L min⁻¹）；21.7 ± 1.7（10 L min⁻¹）；24.0 ± 2.3（15 L min⁻¹）。停止给予高氧空气后，心率（HR）和pH值显著升高。
15 L min⁻¹的SOF似乎比5或10 L min⁻¹更有效。此外，不建议将HR、血压、血乳酸和pH值作为主要结果指标。
