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良性转移性平滑肌瘤病(BML):一种导致空洞性和囊性肺结节的罕见病因。

Benign metastasizing leiomyomatosis (BML): A rare cause of cavitary and cystic pulmonary nodules.

作者信息

Jolissaint Joshua S, Kilbourne Sarah K, LaFortune Kristen, Patel Manojkumar, Lau Christine L

机构信息

University of Virginia School of Medicine, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA, 22903, USA.

University of Virginia, Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia Health System, 1215 Lee Street, Charlottesville, VA, 22903, USA.

出版信息

Respir Med Case Rep. 2015 Sep 21;16:122-4. doi: 10.1016/j.rmcr.2015.09.008. eCollection 2015.

DOI:10.1016/j.rmcr.2015.09.008
PMID:26744676
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4681982/
Abstract

Benign metastasizing leiomyomatosis (BML) is a rare cause of pulmonary lesions found in reproductive age women who have undergone a hysterectomy for uterine leiomyoma. Given the relative rarity of the disease, the management of these lesions varies from surgical (oopherectomy) or medical antiestrogen hormonal therapy to clinical observation and survelliance. The disease generally presents asymptomatically with multiple, well-defined pulmonary nodules discovered incidentally on imaging. We report an atypical presentation of a 46-year-old woman with incidentally found bilateral pulmonary cavitating nodules and cysts, concerning for lymphangioleiomyomatosis (LAM), who was ultimately diagnosed with BML.

摘要

良性转移性平滑肌瘤病(BML)是在因子宫平滑肌瘤接受子宫切除术的育龄女性中发现的肺部病变的罕见病因。鉴于该疾病相对罕见,这些病变的管理方法各不相同,从手术(卵巢切除术)或药物抗雌激素激素治疗到临床观察和监测。该疾病通常无症状,在影像学检查中偶然发现多个边界清晰的肺结节。我们报告了一名46岁女性的非典型表现,她偶然发现双侧肺有空洞性结节和囊肿,疑似淋巴管平滑肌瘤病(LAM),最终被诊断为BML。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785e/4681982/8257e663937b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785e/4681982/f93bc7d46279/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785e/4681982/8257e663937b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785e/4681982/f93bc7d46279/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/785e/4681982/8257e663937b/gr2.jpg

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本文引用的文献

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Cystic and nodular lung disease.囊性和结节性肺病。
Clin Chest Med. 2015 Jun;36(2):299-312, ix. doi: 10.1016/j.ccm.2015.02.011. Epub 2015 Apr 2.
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Benign metastasizing leiomyoma of the lung.良性肺转移平滑肌瘤。
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Benign metastasizing leiomyoma: a rare cause of multiple pulmonary nodules.良性转移性平滑肌瘤:多发性肺结节的罕见病因。
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J Thorac Dis. 2017 Jan;9(1):E1-E5. doi: 10.21037/jtd.2016.11.112.
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Mod Pathol. 2006 Jan;19(1):130-40. doi: 10.1038/modpathol.3800504.
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Benign metastasizing leiomyoma and lymphangioleiomyomatosis: sex-specific diseases?良性转移性平滑肌瘤与淋巴管平滑肌瘤病:性别特异性疾病?
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Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases.子宫良性转移性平滑肌瘤:10例临床、免疫组化及凝集素组织化学数据记录
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Immunohistological detection of estrogen and progesterone receptors in multiple and well differentiated leiomyomatous lung tumors in women with uterine leiomyomas (so-called benign metastasizing leiomyomas). A report on 5 cases.子宫平滑肌瘤女性患者(所谓的良性转移性平滑肌瘤)中多灶性高分化肺平滑肌瘤雌激素和孕激素受体的免疫组织学检测。5例报告。
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