Yang Wenchao, Lu Jiaojiao, Yang Liu, Zhang Jinjin
School of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai, China.
Shanghai Pudong New District Zhoupu Hospital, Shanghai, China.
Iran J Public Health. 2015 Nov;44(11):1445-52.
Matrix metalloproteinase-9 (MMP-9) gene -1562C/T polymorphism could regulate its expression level and thus affected people's predisposition to essential hypertension. However, related studies yielded inconsistent or contradictory results.
To evaluate the association of MMP-9 -1562C/T polymorphism with essential hypertension, we performed a meta-analysis by combining all available independent case-control studies (n=6).A systematic literature search of PubMed, Web of Science, Scopus and CNKI (Chinese National Knowledge Infrastructure) databases was conducted by two researchers independently for all relevant articles published before March 2015.
MMP-9 -1562C/T polymorphism was associated with essential hypertension under the allelic model (T vs.C, OR=1.36, 95% CI=1.17-1.59, P<0.0001). Subsequent sensitivity analysis confirmed the stability of the results. Such association was also observed in the dominant (TT+CT vs. CC, OR=1.30, 95% CI=1.10-1.54, P=0.002) and co-dominant (CT vs. TT+CC, OR=1.27, 95% CI=1.05-1.53, P=0.01) models but not in the recessive model (TT vs. CT+CC, OR=1.30, 95% CI=0.50-3.36, P=0.59).
MMP-9 -1562C/T polymorphism was associated with the risk of essential hypertension.
基质金属蛋白酶-9（MMP-9）基因-1562C/T多态性可调节其表达水平，从而影响人们患原发性高血压的易感性。然而，相关研究结果并不一致或相互矛盾。
为评估MMP-9 -1562C/T多态性与原发性高血压的关联，我们通过合并所有可用的独立病例对照研究（n=6）进行了一项荟萃分析。两名研究人员独立对PubMed、科学网、Scopus和中国知网数据库进行系统文献检索，以查找2015年3月之前发表的所有相关文章。
在等位基因模型下，MMP-9 -1562C/T多态性与原发性高血压相关（T vs.C，比值比=1.36，95%置信区间=1.17-1.59，P<0.0001）。随后的敏感性分析证实了结果的稳定性。在显性模型（TT+CT vs. CC，比值比=1.30，95%置信区间=1.10-1.54，P=0.002）和共显性模型（CT vs. TT+CC，比值比=1.27，95%置信区间=1.05-1.53，P=0.01）中也观察到这种关联，但在隐性模型中未观察到（TT vs. CT+CC，比值比=1.30，95%置信区间=0.50-3.36，P=0.59）。
MMP-9 -1562C/T多态性与原发性高血压风险相关。
