Department of Analytical and Organic Chemistry, Rovira i Virgili University, C/ Marcel⋅lí Domingo 1, 43007, Tarragona, Spain.
Institute of Chemical Research of Catalonia (ICIQ), The Barcelona Institute of Science and Technology, Avda. Països Catalans 16, 43007, Tarragona, Spain.
Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2435-40. doi: 10.1002/anie.201510136. Epub 2016 Jan 8.
Current methods for creatinine quantification suffer from significant drawbacks when aiming to combine accuracy, simplicity, and affordability. Here, an unprecedented synthetic receptor, an aryl-substituted calix[4]pyrrole with a monophosphonate bridge, is reported that displays remarkable affinity for creatinine and the creatininium cation. The receptor works by including the guest in its deep and polar aromatic cavity and establishing directional interactions in three dimensions. When incorporated into a suitable polymeric membrane, this molecule acts as an ionophore. A highly sensitive and selective potentiometric sensor suitable for the determination of creatinine levels in biological fluids, such as urine or plasma, in an accurate, fast, simple, and cost-effective way has thus been developed.
当旨在结合准确性、简单性和可负担性时，目前的肌酸酐定量方法存在明显的缺点。在这里，报道了一种前所未有的合成受体，即具有单膦酸桥的芳基取代杯[4]吡咯，该受体对肌酸酐和肌酸阳离子表现出显著的亲和力。该受体通过将客体包含在其深而极性的芳香空腔中并在三维空间中建立定向相互作用来起作用。当将该分子掺入合适的聚合物膜中时，它可以作为离子载体。因此，已经开发出一种高灵敏度和选择性的电位传感器，可用于以准确、快速、简单和具有成本效益的方式测定生物体液（如尿液或血浆）中的肌酸酐水平。
