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表达组内或组间嵌合血凝素的甲型流感病毒。

Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins.

作者信息

Chen Chi-Jene, Ermler Megan E, Tan Gene S, Krammer Florian, Palese Peter, Hai Rong

机构信息

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA

出版信息

J Virol. 2016 Jan 13;90(7):3789-93. doi: 10.1128/JVI.03060-15.

DOI:10.1128/JVI.03060-15
PMID:26764009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4794680/
Abstract

A panel of influenza A viruses expressing chimeric hemagglutinins (cHA) with intragroup or intergroup head/stalk combinations was generated. Viruses were characterized for growth kinetics and preservation of stalk epitopes. With a few notable exceptions, cHA viruses behaved similarly to wild-type viruses and maintained stalk epitopes, which indicated their potential as vaccine candidates to induce stalk-specific antibodies.

摘要

构建了一组表达具有组内或组间头部/茎部组合的嵌合血凝素（cHA）的甲型流感病毒。对病毒的生长动力学和茎部表位的保留情况进行了表征。除了一些明显的例外，cHA病毒的行为与野生型病毒相似，并保留了茎部表位，这表明它们作为诱导茎部特异性抗体的候选疫苗具有潜力。

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