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本文引用的文献

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Adjuvants and immunization strategies to induce influenza virus hemagglutinin stalk antibodies.诱导流感病毒血凝素茎部抗体的佐剂和免疫策略。
PLoS One. 2013 Nov 6;8(11):e79194. doi: 10.1371/journal.pone.0079194. eCollection 2013.
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Influenza virus hemagglutinin stalk-based antibodies and vaccines.基于流感病毒血凝素茎部的抗体和疫苗。
Curr Opin Virol. 2013 Oct;3(5):521-30. doi: 10.1016/j.coviro.2013.07.007. Epub 2013 Aug 24.
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H7N9 influenza viruses interact preferentially with α2,3-linked sialic acids and bind weakly to α2,6-linked sialic acids.H7N9 流感病毒优先与α2,3 连接的唾液酸相互作用，与α2,6 连接的唾液酸结合较弱。
J Gen Virol. 2013 Nov;94(Pt 11):2417-2423. doi: 10.1099/vir.0.056184-0. Epub 2013 Aug 15.
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Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses.基于血凝素茎部的通用疫苗构建体可预防 2 类流感 A 病毒。
J Virol. 2013 Oct;87(19):10435-46. doi: 10.1128/JVI.01715-13. Epub 2013 Jul 31.
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Characterization of H7N9 influenza A viruses isolated from humans.人感染 H7N9 流感病毒的特征。
Nature. 2013 Sep 26;501(7468):551-5. doi: 10.1038/nature12392. Epub 2013 Jul 10.
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Receptor binding by an H7N9 influenza virus from humans.人感染 H7N9 流感病毒的受体结合。
Nature. 2013 Jul 25;499(7459):496-9. doi: 10.1038/nature12372.
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Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance.新型甲型 H7N9 流感病毒导致的人类疾病不良临床结局与病毒持续排出和抗病毒耐药性的出现之间的关联。
Lancet. 2013 Jun 29;381(9885):2273-9. doi: 10.1016/S0140-6736(13)61125-3. Epub 2013 May 29.
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Human infection with a novel avian-origin influenza A (H7N9) virus.人感染新型甲型 H7N9 流感病毒。
N Engl J Med. 2013 May 16;368(20):1888-97. doi: 10.1056/NEJMoa1304459. Epub 2013 Apr 11.
9
Chimeric hemagglutinin influenza virus vaccine constructs elicit broadly protective stalk-specific antibodies.嵌合血凝素流感病毒疫苗构建体引发广泛保护性茎特异性抗体。
J Virol. 2013 Jun;87(12):6542-50. doi: 10.1128/JVI.00641-13. Epub 2013 Apr 10.
10
H3N2 influenza virus infection induces broadly reactive hemagglutinin stalk antibodies in humans and mice.H3N2 流感病毒感染可诱导人和小鼠产生广泛反应性的血凝素茎部抗体。
J Virol. 2013 Apr;87(8):4728-37. doi: 10.1128/JVI.03509-12. Epub 2013 Feb 13.

基于H3茎部的嵌合血凝素流感病毒构建体可保护小鼠免受H7N9攻击。

H3 stalk-based chimeric hemagglutinin influenza virus constructs protect mice from H7N9 challenge.

作者信息

Krammer Florian, Margine Irina, Hai Rong, Flood Alexander, Hirsh Ariana, Tsvetnitsky Vadim, Chen Dexiang, Palese Peter

机构信息

Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

出版信息

J Virol. 2014 Feb;88(4):2340-3. doi: 10.1128/JVI.03183-13. Epub 2013 Dec 4.

DOI:10.1128/JVI.03183-13
PMID:24307585
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3911549/
Abstract

The recent outbreak of H7N9 influenza virus infections in humans in China has raised concerns about the pandemic potential of this strain. Here, we test the efficacy of H3 stalk-based chimeric hemagglutinin universal influenza virus vaccine constructs to protect against H7N9 challenge in mice. Chimeric hemagglutinin constructs protected from viral challenge in the context of different administration routes as well as with a generic oil-in-water adjuvant similar to formulations licensed for use in humans.

摘要

近期中国出现的人感染H7N9流感病毒疫情引发了对该毒株大流行潜力的担忧。在此，我们测试了基于H3茎部的嵌合血凝素通用流感病毒疫苗构建体在小鼠中抵御H7N9攻击的效力。嵌合血凝素构建体在不同给药途径以及与一种类似于已获许可用于人类的配方的通用水包油佐剂联合使用的情况下，均可保护小鼠免受病毒攻击。