基于流感病毒血凝素茎部的抗体和疫苗。
Influenza virus hemagglutinin stalk-based antibodies and vaccines.
机构信息
Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
出版信息
Curr Opin Virol. 2013 Oct;3(5):521-30. doi: 10.1016/j.coviro.2013.07.007. Epub 2013 Aug 24.
Abstract
Antibodies against the conserved stalk domain of the hemagglutinin are currently being discussed as promising therapeutic tools against influenza virus infections. Because of the conservation of the stalk domain these antibodies are able to broadly neutralize a wide spectrum of influenza virus strains and subtypes. Broadly protective vaccine candidates based on the epitopes of these antibodies, for example, chimeric and headless hemagglutinin structures, are currently under development and show promising results in animals models. These candidates could be developed into universal influenza virus vaccines that protect from infection with drifted seasonal as well as novel pandemic influenza virus strains therefore obviating the need for annual vaccination, and enhancing our pandemic preparedness.
摘要
针对血凝素保守茎部的抗体目前被认为是对抗流感病毒感染的有前途的治疗工具。由于茎部保守，这些抗体能够广泛中和广泛的流感病毒株和亚型。目前正在开发基于这些抗体表位的广谱保护性疫苗候选物，例如嵌合和无头血凝素结构，在动物模型中显示出有希望的结果。这些候选物可以开发成通用流感病毒疫苗，可预防漂移季节性和新型大流行性流感病毒株的感染，因此无需每年接种疫苗，并增强我们的大流行准备。
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本文引用的文献
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Neutralizing antibodies against previously encountered influenza virus strains increase over time: a longitudinal analysis.针对先前遇到的流感病毒株的中和抗体随时间推移而增加：一项纵向分析。
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