Pharmacognosy Department, Faculty of Pharmacy, Ain-Shams University, Cairo, Egypt.
Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Egypt.
Phytother Res. 2015 Dec;29(12):1858-67. doi: 10.1002/ptr.5483. Epub 2015 Oct 13.
Since ancient times, plants and herbal preparations have been used as medicine. Research carried out in the last few decades has verified several such claims. Aloe arborescens Miller, belonging to the Aloe genus (Family Asphodelaceae), is one of the main varieties of Aloe used worldwide. The popularity of the plant in traditional medicine for several ailments (antitumor, immunomodulatory, antiinflammatory, antiulcer, antimicrobial and antifungal activity) focused the investigator's interest on this plant. Most importantly, the reported studies have shown the plant effectiveness on various cancer types such as liver, colon, duodenal, skin, pancreatic, intestinal, lung and kidney types. These multiple biological actions make Aloe an important resource for developing new natural therapies. However, the biological activities of isolated compounds such as glycoprotein, polysaccharides, enzyme and phenolics were insufficient. Considering all these, this contribution provides a systematic review outlining the evidence on the biological efficacy of the plant including the pharmacology and the related mechanisms of action, with specific attention to the various safety precautions, and preclinical and clinical studies, indicating the future research prospects of this plant.
自古以来，植物和草药制剂一直被用作药物。在过去几十年进行的研究验证了其中的一些说法。阿罗埃洛树（Aloe arborescens Miller），属于阿罗埃洛属（天门冬科），是全世界广泛使用的阿罗埃洛属植物的主要品种之一。该植物在传统医学中用于多种疾病（抗肿瘤、免疫调节、抗炎、抗溃疡、抗菌和抗真菌活性），引起了研究人员的兴趣。最重要的是，报告的研究表明，该植物对各种癌症类型（肝、结肠、十二指肠、皮肤、胰腺、肠道、肺和肾）有效。这些多种生物学作用使阿罗埃洛成为开发新的天然疗法的重要资源。然而，分离化合物（如糖蛋白、多糖、酶和酚类）的生物学活性还不够。考虑到所有这些，本综述提供了一个系统的综述，概述了该植物的生物学功效的证据，包括药理学和相关的作用机制，特别注意各种安全预防措施，以及临床前和临床研究，指出了该植物的未来研究前景。
