Li Xue-Feng, Shen Ming, Cai Jun-Wei, Zeng Yu-Qin, Li Min, Yang Gong-Li, Xu Xiao-Ming, Hu Yuan-Yuan
Department of Endocrinology, Taihe Hospital, Hubei University of Medicine Shiyan 442000, P. R. China.
Jiangsu Key Laboratory of Oral Diseases, Department of Dental Implant, Affiliated Hospital of Stomatology, Nanjing Medical University No. 140 Hanzhong Road, Nanjing 210029, P. R. China.
Int J Clin Exp Med. 2015 Oct 15;8(10):17623-33. eCollection 2015.
The association between Interleukin-17(IL-17) gene polymorphisms and Helicobacter pylori (H. pylori) infection and gastric cancer susceptibility were inconsistent. We therefore performed a comprehensive meta-analysis about all three genetic polymorphisms of IL-17 to derive a more precise estimation.
PubMed, Embase, CNKI and Wanfang databases were researched on the associations between IL-17A rs2275913G>A, rs3748067C>T and IL-17F rs763780 T>C and gastric cancer risk. Odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the relationships. Publication bias, sensitivity and cumulative analysis was conducted to guarantee the strength of meta-analysis.
Overall, eleven related studies involving 4,478 cases and 5,612 controls were collected. Significantly increased risk between IL-17A rs2275913G>A polymorphism and gastric cancer were observed (A vs. G: OR = 1.22, 95% CI = 1.08-1.37, P<0.01, I(2) = 72.3%; AA vs. GG: OR = 1.55, 95% CI = 1.21-1.99, P<0.01, I(2) = 74.3%; GA + AA vs. GG: OR = 1.19, 95% CI = 1.05-1.39, P<0.01, I(2) = 48.2%; AA vs. GG + GA: OR = 1.50, 95% CI = 1.16-1.95, P<0.01, I(2) = 81.2%). For IL-17F rs3748067C>T and rs763780 T>C polymorphisms, only few significantly increased risk could be found in genetic models. Moreover, H. pylori infection also be proved to increase the risk of gastric cancer combined with rs3748067C>T mutation.
Our meta-analysis suggests that the three IL-17 polymorphisms were associated with a significantly increased risk of gastric cancer, especially in Chinese.
白细胞介素-17（IL-17）基因多态性与幽门螺杆菌（H. pylori）感染及胃癌易感性之间的关联并不一致。因此，我们对IL-17的所有三种基因多态性进行了全面的荟萃分析，以得出更精确的估计。
检索PubMed、Embase、CNKI和万方数据库，研究IL-17A rs2275913G>A、rs3748067C>T以及IL-17F rs763780 T>C与胃癌风险之间的关联。应用比值比（OR）及95%置信区间（CI）评估二者关系。进行发表偏倚、敏感性和累积分析以确保荟萃分析的强度。
总体而言，共收集到11项相关研究，涉及4478例病例和5612例对照。观察到IL-17A rs2275913G>A多态性与胃癌风险显著增加相关（A与G相比：OR = 1.22，95%CI = 1.08 - 1.37，P<0.01，I(2)=72.3%；AA与GG相比：OR = 1.55，95%CI = 1.21 - 1.99，P<0.01，I(2)=74.3%；GA + AA与GG相比：OR = 1.19，95%CI = 1.05 - 1.39，P<0.01，I(2)=48.2%；AA与GG + GA相比：OR = 1.50，95%CI = 1.16 - 1.95，P<0.01，I(2)=81.2%）。对于IL-17F rs3748067C>T和rs763780 T>C多态性，在遗传模型中仅发现少数显著增加的风险。此外，幽门螺杆菌感染也被证明与rs3748067C>T突变共同增加胃癌风险。
我们的荟萃分析表明，IL-17的三种多态性与胃癌风险显著增加相关，尤其是在中国人群中。
