Zhu Hong, Shen Yongchun, Deng Kai, Liu Xia, Zhao Yaqin, Liu Taiguo, Huang Ying
Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University Chengdu 610041, China.
Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University Chengdu 610041, China.
Int J Clin Exp Med. 2015 Oct 15;8(10):18494-9. eCollection 2015.
Many studies have investigated whether ascitic cholesterol can aid in diagnosis of malignant related ascites (MRA), and the results have varied considerably. To gain a more reliable answer to this question, we meta-analyzed the literature on using ascitic cholesterol as diagnostic tests to help identify MRA. Literature databases were systematically searched for studies examining accuracy of ascitic cholesterol for diagnosing MRA. Data on sensitivity, specificity, positive/negative likelihood ratio (PLR/NLR), and diagnostic odds ratio (DOR) were pooled using random effects models. Summary receiver operating characteristic (SROC) curves and area under the curve (AUC) were used to summarize overall test performance. At last, our meta-analysis included 8 studies involving 743 subjects. Summary estimates for ascitic cholesterol in the diagnosis of MRA were as follows: sensitivity, 0.82 (95% CI 0.78 to 0.86); specificity, 0.90 (95% CI 0.87 to 0.93); PLR, 9.24 (95% CI 4.58 to 18.66); NLR, 0.16 (95% CI 0.08 to 0.32); and DOR, 66.96 (95% CI 18.83 to 238.11). The AUC was 0.96. The ascitic cholesterol level is helpful for the diagnosis of MRA. Nevertheless, the results of ascitic cholesterol assays should be interpreted in parallel with the results of traditional tests and clinical information.
许多研究探讨了腹水中的胆固醇是否有助于诊断恶性相关腹水（MRA），结果差异很大。为了更可靠地回答这个问题，我们对有关使用腹水胆固醇作为诊断试验以帮助识别MRA的文献进行了荟萃分析。系统检索文献数据库，以查找研究腹水胆固醇诊断MRA准确性的研究。使用随机效应模型汇总敏感性、特异性、阳性/阴性似然比（PLR/NLR）和诊断比值比（DOR）的数据。采用汇总受试者工作特征（SROC）曲线和曲线下面积（AUC）来总结总体测试性能。最后，我们的荟萃分析纳入了8项研究，涉及743名受试者。腹水胆固醇诊断MRA的汇总估计如下：敏感性为0.82（95%CI 0.78至0.86）；特异性为0.90（95%CI 0.87至0.93）；PLR为9.24（95%CI 4.58至18.66）；NLR为0.16（95%CI 0.08至0.32）；DOR为66.96（95%CI 18.83至238.11）。AUC为0.96。腹水胆固醇水平有助于MRA的诊断。然而，腹水胆固醇检测结果应与传统检测结果和临床信息一并解读。
