Aiba S, Tagami H
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
J Cutan Pathol. 1989 Aug;16(4):207-10. doi: 10.1111/j.1600-0560.1989.tb00042.x.
Plasma cell orificial mucositis is a benign idiopathic condition of orificial mucous membranes characterized histologically by a dense band-like plasmacytic infiltrate. We studied 8 cases of this disease by immunohistochemical methods for subsets of immunoglobulin-producing cells. The infiltrating plasma cells were found to produce mostly IgG and IgA with the predominance of kappa chain-producing cells over lambda chain-producing cells. This polyclonal plasma cell infiltrate composed of IgG- and IgA-producing cells is in accordance with the pattern observed in the inflammatory infiltrate around certain epidermal neoplasms accompanied by the plasmacytic infiltrate, such as actinic keratosis, Bowen's disease, squamous cell carcinoma, and syringocystadenoma papilliferum.
浆细胞性口周黏膜炎是一种口周黏膜的良性特发性疾病，组织学特征为致密的带状浆细胞浸润。我们采用免疫组化方法对8例该疾病患者的免疫球蛋白产生细胞亚群进行了研究。发现浸润的浆细胞主要产生IgG和IgA，κ链产生细胞多于λ链产生细胞。这种由产生IgG和IgA的细胞组成的多克隆浆细胞浸润，与在某些伴有浆细胞浸润的表皮肿瘤（如光化性角化病、鲍温病、鳞状细胞癌和乳头状汗管囊腺瘤）周围的炎性浸润中观察到的模式一致。
